{"id":"W4406463774","doi":"10.7554/elife.100541.2","title":"Pharmacologic Activation of Integrated Stress Response Kinases Inhibits Pathologic Mitochondrial Fragmentation","year":2025,"lang":"en","type":"preprint","venue":"eLife","topic":"Mitochondrial Function and Pathology","field":"Biochemistry, Genetics and Molecular Biology","cited_by":0,"is_retracted":false,"has_abstract":true,"ca_institutions":"Alberta Children's Hospital; University of Calgary","funders":"","keywords":"Kinase; Fragmentation (computing); Cell biology; Mitochondrion; Chemistry; Biology","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001338343,0.0003119135,0.0002169601,0.0002079569,0.0001355583,0.0002482706,0.0003037106,0.0002229403,0.002544219],"category_scores_gemma":[0.00009549283,0.00009434217,0.000187171,0.000105909,0.0002688563,0.000136316,0.0001647706,0.000574422,0.0006244878],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0002976334,"about_ca_system_score_gemma":0.0002944595,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0005476426,"about_ca_topic_score_gemma":0.001080016,"domain_scores_codex":[0.9999073,0.00001258369,0.00001044817,0.00001726424,0.00002565895,0.00002672135],"domain_scores_gemma":[0.9999522,0.000009418451,0.00001125352,0.000007887322,0.000005786795,0.0000134981],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0006107975,0.0002361066,0.000206251,0.00009711904,0.00001960548,0.0000726732,0.00001840731,0.0002697566,0.9924862,0.000625089,0.0005839897,0.004773793],"study_design_scores_gemma":[0.00009188493,0.0004976604,0.00119619,0.000009110239,0.00001268591,0.0001519122,0.0000361299,0.0006855704,0.9917487,0.000111022,0.005455996,0.000003312417],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9834288,0.002716249,0.003789843,0.0005683935,0.0001683136,0.00006764234,0.0009962111,0.0003120528,0.007952406],"genre_scores_gemma":[0.987588,0.00138026,0.003354767,0.0001123742,0.00002271019,0.00006485326,0.0008768091,0.00004163929,0.006558645],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.002544219,"threshold_uncertainty_score":0.008511305,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.02126106118749495,"score_gpt":0.3060134559420881,"score_spread":0.2847523947545932,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}