{"id":"W4406467149","doi":"10.1113/jp286367","title":"Skin disease‐associated <i>GJB4</i> variants differentially influence connexin stability, cell viability and channel function","year":2025,"lang":"en","type":"article","venue":"The Journal of Physiology","topic":"Connexins and lens biology","field":"Biochemistry, Genetics and Molecular Biology","cited_by":1,"is_retracted":false,"has_abstract":true,"ca_institutions":"Western University","funders":"Natural Sciences and Engineering Research Council of Canada; Canadian Institutes of Health Research","keywords":"Gap junction; Connexin; Gating; Connexon; Patch clamp; Wild type; Cell biology; Chemistry; Biophysics; Biology; Intracellular; Gene; Genetics; Electrophysiology; Mutant; Neuroscience","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001006995,0.0002174447,0.0001561048,0.0001063296,0.0001012505,0.0001963501,0.00009378023,0.0001766801,0.001182635],"category_scores_gemma":[0.0001194227,0.00006031934,0.0001616631,0.00007877378,0.0001763946,0.0001037182,0.0001263724,0.0002408777,0.0002454657],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0001375213,"about_ca_system_score_gemma":0.00005886765,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00053327,"about_ca_topic_score_gemma":0.0005953066,"domain_scores_codex":[0.9998876,0.00002579395,0.00001357391,0.00002279454,0.00002392789,0.00002624128],"domain_scores_gemma":[0.9999102,0.00001876934,0.00003029497,0.00001162378,0.000009318243,0.00001973568],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00005641535,0.000007554108,0.0006233082,0.000005605482,0.000004413506,0.0001050509,0.000008403093,0.00003016116,0.9988734,0.00002201943,0.00001049606,0.0002532033],"study_design_scores_gemma":[0.00001535027,0.000367369,0.04725788,0.000005738892,0.00004322388,0.002984257,0.0001107094,0.001350464,0.9467185,0.00006544006,0.00107166,0.000009366739],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9992759,0.00009500608,0.0002884831,0.00001096374,0.000003337329,0.000003904704,0.00007121723,0.00001039858,0.0002407087],"genre_scores_gemma":[0.9994757,0.00004755404,0.0001981454,0.000009398641,0.000001616734,0.000003260084,0.00007575416,0.000008598971,0.0001799375],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001182635,"threshold_uncertainty_score":0.003956318,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.006145281952265198,"score_gpt":0.2180992507708538,"score_spread":0.2119539688185886,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}