{"id":"W4406480376","doi":"10.37349/etat.2025.1002286","title":"Implications of noncoding RNAs for cancer therapy: Are we aiming at the right targets?","year":2025,"lang":"en","type":"review","venue":"Exploration of Targeted Anti-tumor Therapy","topic":"Cancer-related molecular mechanisms research","field":"Biochemistry, Genetics and Molecular Biology","cited_by":1,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of British Columbia","funders":"","keywords":"Carcinogenesis; Biology; Epigenetics; microRNA; Non-coding RNA; Computational biology; Cancer; Suppressor; Gene; Genetics; Cancer research","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0009130164,0.000931017,0.001302856,0.001125968,0.0003418027,0.001132869,0.001225362,0.001878559,0.003953018],"category_scores_gemma":[0.001008948,0.0002456255,0.0004454016,0.001232574,0.00105405,0.002442979,0.0006644755,0.003814934,0.002758067],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.001002679,"about_ca_system_score_gemma":0.001081145,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0009468849,"about_ca_topic_score_gemma":0.001857748,"domain_scores_codex":[0.9997761,0.00005387331,0.00002332537,0.00003331803,0.00008623852,0.00002709289],"domain_scores_gemma":[0.999542,0.0002645812,0.00003406567,0.0000175744,0.00009625489,0.00004549986],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"design_other","study_design_gemma":"not_applicable","study_design_scores_codex":[0.00008381426,0.00006710304,0.0000921695,0.008310149,0.00005387707,0.0002532568,0.00008435499,0.0004882595,0.002297933,0.01657379,0.07636175,0.8953334],"study_design_scores_gemma":[0.00001285859,0.00005307256,0.0001935262,0.001471604,0.00002495873,0.0005641772,0.00004506955,0.00006467236,0.0002639604,0.005783936,0.991511,0.0000112456],"study_design_candidate":"not_applicable","study_design_consensus":null,"genre_codex":"review","genre_gemma":"review","genre_scores_codex":[0.00004615487,0.9971517,0.0001801176,0.001165809,0.0004821321,0.000002401837,0.000007722836,0.000007793762,0.0009561687],"genre_scores_gemma":[0.000477603,0.9972841,0.0002240109,0.0007622898,0.000377662,0.000006743511,0.0000147297,0.000002272745,0.0008505693],"genre_candidate":"review","genre_consensus":"review","teacher_disagreement_score":0.003953018,"threshold_uncertainty_score":0.01322412,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.07605753874057238,"score_gpt":0.3799809298330731,"score_spread":0.3039233910925007,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}