{"id":"W4406481315","doi":"10.3389/fimmu.2024.1484462","title":"Potential implications of granzyme B in keloids and hypertrophic scars through extracellular matrix remodeling and latent TGF-β activation","year":2025,"lang":"en","type":"article","venue":"Frontiers in Immunology","topic":"Dermatologic Treatments and Research","field":"Medicine","cited_by":9,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of Toronto; St. Michael's Hospital; International Collaboration On Repair Discoveries; Vancouver Coastal Health Research Institute; University of British Columbia","funders":"","keywords":"Extracellular matrix; Granzyme B; Extracellular; Transforming growth factor; Granzyme; Keloid; Cell biology; Medicine; Immunology; Biology; Pathology; Perforin; Immune system; T cell","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001002258,0.00008807494,0.0002998209,0.0003205114,0.00004730988,0.000006154988,0.00005368474,0.0001600802,0.000004292374],"category_scores_gemma":[0.00003006409,0.00007253559,0.00002646958,0.0002384786,0.0002091466,0.0000615203,0.00005987484,0.0001941364,3.600595e-7],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00006973258,"about_ca_system_score_gemma":0.00005655699,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0002004044,"about_ca_topic_score_gemma":0.000003900051,"domain_scores_codex":[0.9992175,0.00006302896,0.0002663663,0.0002085789,0.00005812799,0.0001863747],"domain_scores_gemma":[0.9997033,0.00002434685,0.00004540039,0.0001702678,0.0000403971,0.00001621069],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"observational","study_design_gemma":"observational","study_design_scores_codex":[0.001035423,0.0005544575,0.7290261,0.0002344889,0.0003197644,0.00007375918,0.0007386142,0.0002020102,0.1920789,0.006502226,0.0005668016,0.06866743],"study_design_scores_gemma":[0.006105664,0.0002124282,0.9657446,0.0002622742,0.00008315999,0.0002168858,0.001032379,0.00417505,0.003500396,0.01750317,0.001022117,0.0001418543],"study_design_candidate":"observational","study_design_consensus":"observational","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9662092,0.02197773,0.007732503,0.003388971,0.0001433121,0.0003302339,0.000002423879,0.00001140975,0.0002042041],"genre_scores_gemma":[0.9881755,0.004394957,0.006873215,0.00002550497,0.000005108116,0.00002387422,0.00001625094,0.00000605544,0.0004795467],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.2367185,"threshold_uncertainty_score":0.2957915,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01360677290644368,"score_gpt":0.2909465540333244,"score_spread":0.2773397811268807,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}