{"id":"W4406500448","doi":"10.1126/sciimmunol.adp5218","title":"Anti–immune complex antibodies are elicited during repeated immunization with HIV Env immunogens","year":2025,"lang":"en","type":"article","venue":"Science Immunology","topic":"HIV Research and Treatment","field":"Immunology and Microbiology","cited_by":4,"is_retracted":false,"has_abstract":true,"ca_institutions":"Institute of Infection and Immunity","funders":"Office of Science; Oregon Health and Science University; National Institutes of Health; National Institute of General Medical Sciences; amfAR, The Foundation for AIDS Research; Biological and Environmental Research; National Institute of Allergy and Infectious Diseases; Bill and Melinda Gates Foundation; U.S. Department of Energy","keywords":"Immunization; Antibody; Immunology; Immune system; Virology; Human immunodeficiency virus (HIV); AIDS Vaccines; Biology; Medicine; Vaccine trial","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001925713,0.0002341142,0.0001489055,0.0002216418,0.0001187525,0.0002219404,0.0002098405,0.000339235,0.0008371335],"category_scores_gemma":[0.0001684401,0.0001333677,0.0002015619,0.00009674116,0.0001942146,0.0001960656,0.0002260013,0.0004530689,0.0002210418],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0002079408,"about_ca_system_score_gemma":0.00008911831,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0003812748,"about_ca_topic_score_gemma":0.0003669187,"domain_scores_codex":[0.9998745,0.00002019785,0.000005364745,0.00002572078,0.00003547458,0.00003866707],"domain_scores_gemma":[0.9998958,0.00001875544,0.000030128,0.00001574127,0.0000216624,0.00001780858],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00002900407,0.00001269175,0.0008642157,0.00002067576,0.00000746969,0.00007647678,0.00002131337,0.00006977868,0.9967304,0.000100737,0.00002626935,0.002040925],"study_design_scores_gemma":[0.00001264552,0.0004320572,0.03426158,0.00001022024,0.00003009687,0.001377897,0.00006264033,0.001316512,0.9591759,0.000218462,0.003095726,0.000006283331],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9941753,0.0005989814,0.003706275,0.00002810529,0.000008833311,0.00001484682,0.00003578675,0.00003353935,0.001398399],"genre_scores_gemma":[0.9968881,0.0002883832,0.001821514,0.0000730137,0.000005567712,0.000008508771,0.00008304745,0.00001021073,0.0008216039],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.0008371335,"threshold_uncertainty_score":0.002800524,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01150372960857473,"score_gpt":0.2665772329644617,"score_spread":0.255073503355887,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}