{"id":"W4406500448","doi":"10.1126/sciimmunol.adp5218","title":"Anti–immune complex antibodies are elicited during repeated immunization with HIV Env immunogens","year":2025,"lang":"en","type":"article","venue":"Science Immunology","topic":"HIV Research and Treatment","field":"Immunology and Microbiology","cited_by":4,"is_retracted":false,"has_abstract":true,"ca_institutions":"Institute of Infection and Immunity","funders":"Office of Science; Oregon Health and Science University; National Institutes of Health; National Institute of General Medical Sciences; amfAR, The Foundation for AIDS Research; Biological and Environmental Research; National Institute of Allergy and Infectious Diseases; Bill and Melinda Gates Foundation; U.S. Department of Energy","keywords":"Immunization; Antibody; Immunology; Immune system; Virology; Human immunodeficiency virus (HIV); AIDS Vaccines; Biology; Medicine; Vaccine trial","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":["metaepi_narrow","sts","insufficient_payload"],"consensus_categories":["sts"],"category_scores_codex":[0.0004298814,0.0003365545,0.0005655916,0.0009602796,0.001825822,0.00008740927,0.0009685714,0.0002155707,0.0005287093],"category_scores_gemma":[0.0002624154,0.0002657251,0.00008753507,0.002108823,0.003646363,0.0003237111,0.0005130642,0.000463736,0.001072803],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0002474531,"about_ca_system_score_gemma":0.0004053581,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0003655687,"about_ca_topic_score_gemma":0.00003630829,"domain_scores_codex":[0.9972411,0.000277321,0.0004853579,0.0007268235,0.000120446,0.001148902],"domain_scores_gemma":[0.9980875,0.0001094924,0.000229155,0.001042838,0.0004976304,0.00003334731],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"observational","study_design_scores_codex":[0.0003598201,0.0002153882,0.04497994,0.0000191871,0.00043938,0.00003775808,0.0003122623,0.00002670894,0.9517078,0.0006260562,0.0001416039,0.001134141],"study_design_scores_gemma":[0.00220415,0.00017504,0.5913379,0.0001018153,0.00003495824,0.0001343918,0.0008589255,0.000009574784,0.4024099,0.00003366383,0.002493131,0.0002065974],"study_design_candidate":"bench_or_experimental","study_design_consensus":null,"genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9879941,0.006366984,0.0001650448,0.0009903824,0.0003885655,0.0004937921,0.00005718813,0.0002488602,0.003295133],"genre_scores_gemma":[0.9938349,0.0005958738,0.0001792517,0.00006015123,0.000007047369,0.00004936645,0.0003793925,0.00001852473,0.004875558],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.5492979,"threshold_uncertainty_score":0.9999795,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01150372960857473,"score_gpt":0.2665772329644617,"score_spread":0.255073503355887,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}