{"id":"W4406503203","doi":"10.1093/ndt/gfaf013","title":"DEFENDER trial: dapagliflozin for critically ill patients with acute organ dysfunction—implications for clinicians","year":2025,"lang":"en","type":"article","venue":"Nephrology Dialysis Transplantation","topic":"Diabetes Treatment and Management","field":"Medicine","cited_by":1,"is_retracted":false,"has_abstract":true,"ca_institutions":"St. Thomas Hospital","funders":"","keywords":"Medicine; Dapagliflozin; Critically ill; Intensive care medicine; Organ dysfunction; Internal medicine; Sepsis; Diabetes mellitus","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.003567903,0.0006917004,0.001883305,0.0003437146,0.0002556535,0.002022871,0.0006708695,0.002382013,0.01423743],"category_scores_gemma":[0.009931396,0.0001700029,0.001613603,0.0005094937,0.0004300267,0.001683621,0.0006254208,0.004048281,0.002115362],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0007209503,"about_ca_system_score_gemma":0.001233301,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0003891662,"about_ca_topic_score_gemma":0.001270253,"domain_scores_codex":[0.9985766,0.0008963709,0.0001271266,0.0001515225,0.0001739555,0.00007437631],"domain_scores_gemma":[0.9967139,0.001590698,0.0007046944,0.000152151,0.0002891007,0.0005495477],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"design_other","study_design_gemma":"randomized_trial","study_design_scores_codex":[0.2022382,0.001230517,0.005732299,0.01368848,0.00266017,0.0002152086,0.0001366781,0.0008021383,0.001309047,0.005863563,0.2617222,0.5044015],"study_design_scores_gemma":[0.5682703,0.02619676,0.03233825,0.02969277,0.007037289,0.0005480301,0.0003540522,0.003345678,0.0006895452,0.01829186,0.3130397,0.0001955728],"study_design_candidate":"randomized_trial","study_design_consensus":null,"genre_codex":"review","genre_gemma":"empirical","genre_scores_codex":[0.1012382,0.4957238,0.003559706,0.2862176,0.03007321,0.004049295,0.0151759,0.0004253045,0.06353693],"genre_scores_gemma":[0.4377942,0.2137304,0.01415356,0.2297034,0.0556011,0.01081331,0.0122274,0.000282064,0.0256945],"genre_candidate":"empirical","genre_consensus":null,"teacher_disagreement_score":0.01423743,"threshold_uncertainty_score":0.04762894,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.0156544956876482,"score_gpt":0.2934419602578549,"score_spread":0.2777874645702066,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}