{"id":"W4406525793","doi":"10.3390/curroncol32010046","title":"Treatment Options for Advanced Non-Small Cell Lung Cancer After Failure of Previous Immune Checkpoint Inhibitors and Chemotherapy: Meta-Analysis of Five Randomized Controlled Trials","year":2025,"lang":"en","type":"review","venue":"Current Oncology","topic":"Cancer Immunotherapy and Biomarkers","field":"Medicine","cited_by":1,"is_retracted":false,"has_abstract":true,"ca_institutions":"","funders":"","keywords":"Medicine; Chemotherapy; Oncology; Lung cancer; Meta-analysis; Randomized controlled trial; Internal medicine; Immune system; Cancer; Nivolumab; Immunotherapy; Bioinformatics; Immunology","routes":{"ca_aff":false,"ca_fund":false,"ca_venue":true,"about_ca":false,"invisible_to_affiliation_only":true},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.02582375,0.003289188,0.0195731,0.005789063,0.0005329014,0.003248394,0.002137744,0.002220792,0.003801907],"category_scores_gemma":[0.03044953,0.001438307,0.06696203,0.005041782,0.0007921265,0.001753579,0.001469868,0.002455939,0.0002914712],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.002474763,"about_ca_system_score_gemma":0.001713842,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.003136167,"about_ca_topic_score_gemma":0.005747137,"domain_scores_codex":[0.980224,0.01260498,0.003804463,0.00165611,0.001299243,0.000411174],"domain_scores_gemma":[0.9766046,0.01773354,0.003540812,0.0009530961,0.0007977304,0.000370224],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"meta_analysis","study_design_gemma":"meta_analysis","study_design_scores_codex":[0.007151084,0.0000346866,0.002303096,0.04416815,0.9417035,0.00007086507,0.0000255087,0.0008336988,0.0001931152,0.00006048764,0.0001720829,0.003283739],"study_design_scores_gemma":[0.001750218,0.0003321854,0.001739281,0.001993421,0.9932279,0.00004325279,0.00001675612,0.0002692041,0.00007908498,0.0001202746,0.0004150246,0.00001340759],"study_design_candidate":"meta_analysis","study_design_consensus":"meta_analysis","genre_codex":"review","genre_gemma":"review","genre_scores_codex":[0.03583815,0.9581245,0.002527994,0.0004467161,0.0004995573,0.0007781117,0.001105687,0.00009563916,0.0005836203],"genre_scores_gemma":[0.7395742,0.248067,0.005764458,0.001378206,0.0004270673,0.002011006,0.002099138,0.00008854295,0.0005903851],"genre_candidate":"review","genre_consensus":"review","teacher_disagreement_score":0.02582375,"threshold_uncertainty_score":0.1365706,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.08355211196076115,"score_gpt":0.4365381157456695,"score_spread":0.3529860037849083,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}