{"id":"W4406525874","doi":"10.1152/ajplung.00131.2024","title":"Cannabis vaping elicits transcriptomic and metabolomic changes involved in inflammatory, oxidative stress, and cancer pathways in human bronchial epithelial cells","year":2025,"lang":"en","type":"article","venue":"American Journal of Physiology-Lung Cellular and Molecular Physiology","topic":"Cannabis and Cannabinoid Research","field":"Medicine","cited_by":7,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of Ottawa; McGill University; Christie (Canada); McGill University Health Centre","funders":"Fonds de Recherche du Québec - Santé; Natural Sciences and Engineering Research Council of Canada; Fonds de recherche du Québec – Nature et technologies; Canadian Institutes of Health Research; Fonds de recherche du Québec","keywords":"Oxidative stress; Transcriptome; Metabolomics; Cannabis; Inflammation; Cancer cell; Biology; Cancer; Pharmacology; Medicine; Immunology; Bioinformatics; Gene; Biochemistry; Genetics; Gene expression","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001173316,0.0002811312,0.0004390062,0.000487703,0.0005249029,0.0004560861,0.000118854,0.0003565429,0.002132116],"category_scores_gemma":[0.0002276093,0.0001510873,0.0005453569,0.0004449636,0.0002434962,0.0002174623,0.0004337522,0.0005081175,0.0002996201],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0002544998,"about_ca_system_score_gemma":0.0004641077,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.003271077,"about_ca_topic_score_gemma":0.005889335,"domain_scores_codex":[0.9998192,0.00002123972,0.00001051234,0.0000481169,0.00004688297,0.00005408557],"domain_scores_gemma":[0.9999169,0.00001686251,0.00001484249,0.000008550111,0.00002445725,0.00001835976],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00136733,0.00009494356,0.01251879,0.0004081961,0.00009880518,0.0003167739,0.0002006035,0.0001346506,0.9763927,0.0001057125,0.0004698915,0.00789156],"study_design_scores_gemma":[0.00008540501,0.001539626,0.6117567,0.0001599618,0.000488931,0.001238198,0.001891617,0.002680298,0.3671499,0.0008442558,0.01206488,0.000100209],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9820908,0.007765057,0.001520647,0.0004632381,0.0001551625,0.00007981271,0.005865145,0.00007172654,0.001988487],"genre_scores_gemma":[0.9844288,0.003890326,0.001592691,0.0004189059,0.00005571944,0.0001336098,0.005254313,0.00002208155,0.004203603],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.003271077,"threshold_uncertainty_score":0.007132649,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.006876860272064622,"score_gpt":0.2634587527497859,"score_spread":0.2565818924777212,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}