{"id":"W4406536306","doi":"10.4103/nrr.nrr-d-24-00865","title":"Systematic review of amyloid-beta clearance proteins from the brain to the periphery: implications for Alzheimer’s disease diagnosis and therapeutic targets","year":2025,"lang":"en","type":"article","venue":"Neural Regeneration Research","topic":"Alzheimer's disease research and treatments","field":"Medicine","cited_by":7,"is_retracted":false,"has_abstract":true,"ca_institutions":"","funders":"Shengjing Hospital; China Medical University; National Natural Science Foundation of China","keywords":"Disease; Amyloid beta; Medicine; Amyloid (mycology); BETA (programming language); Neuroscience; Alzheimer's disease; Pathology; Biology; Computer science","routes":{"ca_aff":false,"ca_fund":false,"ca_venue":false,"about_ca":true,"invisible_to_affiliation_only":true},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0009865023,0.0001411084,0.0003342021,0.00007773199,0.0005573356,0.00007983068,0.0002806983,0.00003602022,0.0000384436],"category_scores_gemma":[0.00147785,0.00007293088,0.000133765,0.0005705607,0.0001752115,0.000055956,0.00009982086,0.0001820929,0.00001254957],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00005456329,"about_ca_system_score_gemma":0.000367355,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0001045108,"about_ca_topic_score_gemma":0.00007190849,"domain_scores_codex":[0.9976798,0.0007303363,0.0003622855,0.0003583521,0.0005475971,0.0003216011],"domain_scores_gemma":[0.9968673,0.001333287,0.00006901832,0.0008371806,0.0006485054,0.000244724],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"not_applicable","study_design_gemma":"observational","study_design_scores_codex":[0.00615197,0.004276229,0.06528167,0.3106269,0.03589674,0.00004477679,0.002013332,0.0001602999,0.01336149,0.06172662,0.3827989,0.1176611],"study_design_scores_gemma":[0.008162294,0.003562038,0.6998942,0.1873172,0.01473641,0.00001660409,0.000980784,0.01423837,0.03706861,0.007719573,0.02517254,0.001131338],"study_design_candidate":"observational","study_design_consensus":null,"genre_codex":"review","genre_gemma":"empirical","genre_scores_codex":[0.02224005,0.6100757,0.0001995231,0.3515283,0.00003517462,0.01550886,0.0003209054,0.00002277602,0.00006882544],"genre_scores_gemma":[0.9647594,0.01306156,0.0001000528,0.006384448,0.0001117695,0.01514019,0.0001646513,0.0000241781,0.0002537071],"genre_candidate":"empirical","genre_consensus":null,"teacher_disagreement_score":0.9425194,"threshold_uncertainty_score":0.4286631,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.1012679242247579,"score_gpt":0.4211059256858023,"score_spread":0.3198380014610444,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}