{"id":"W4406536441","doi":"10.1111/liv.16201","title":"Maralixibat Reduces Serum Bile Acids and Improves Cholestatic Pruritus in Adolescents With Alagille Syndrome","year":2025,"lang":"en","type":"article","venue":"Liver International","topic":"Pediatric Hepatobiliary Diseases and Treatments","field":"Medicine","cited_by":6,"is_retracted":false,"has_abstract":true,"ca_institutions":"Hospital for Sick Children; University of Toronto; Toronto General Hospital","funders":"","keywords":"Alagille syndrome; Cholestasis; Medicine; Gastroenterology; Internal medicine; Bile acid","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.000820654,0.0002834969,0.0007646264,0.0001739243,0.0001913619,0.0002515688,0.0001902046,0.0003383681,0.001845248],"category_scores_gemma":[0.001474551,0.0001187668,0.000465004,0.0001045161,0.0001625491,0.0002398455,0.0002311161,0.0007463775,0.0001976319],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0002893244,"about_ca_system_score_gemma":0.0003173293,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0005236077,"about_ca_topic_score_gemma":0.001069844,"domain_scores_codex":[0.9997213,0.0001348906,0.00003062029,0.00002983556,0.00004199639,0.00004131337],"domain_scores_gemma":[0.9992917,0.0002019258,0.0002300575,0.00002573878,0.00008185574,0.0001687837],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"observational","study_design_gemma":"nonrandomized_trial","study_design_scores_codex":[0.05703212,0.009354194,0.5083877,0.003040863,0.001353261,0.00431443,0.001614335,0.001383847,0.08090755,0.0005198005,0.005067554,0.3270244],"study_design_scores_gemma":[0.01687758,0.1138743,0.8202059,0.001135681,0.001438368,0.01262208,0.001211274,0.002919713,0.01862767,0.0005319477,0.01050137,0.00005400202],"study_design_candidate":"nonrandomized_trial","study_design_consensus":null,"genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9961869,0.002576351,0.0001936015,0.0002272971,0.00002826952,0.00007770676,0.00008125864,0.00002695586,0.0006016154],"genre_scores_gemma":[0.9976712,0.0008733042,0.0006638058,0.0002284689,0.00002171998,0.00008687795,0.0001140326,0.000005296481,0.0003353002],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001845248,"threshold_uncertainty_score":0.006172955,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.005441835888618849,"score_gpt":0.2494953106956253,"score_spread":0.2440534748070065,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}