{"id":"W4406536614","doi":"10.1038/s41591-024-03462-0","title":"Tucatinib and trastuzumab in HER2-mutated metastatic breast cancer: a phase 2 basket trial","year":2025,"lang":"en","type":"article","venue":"Nature Medicine","topic":"HER2/EGFR in Cancer Research","field":"Medicine","cited_by":18,"is_retracted":false,"has_abstract":true,"ca_institutions":"","funders":"FUJIFILM Toyama Chemical; Bayer Yakuhin; MSD K.K.; Chugai Pharmaceutical; Eli Lilly Japan; Sierra Oncology; Sirtex Medical; Ono Pharmaceutical; Astellas Pharma; Swedish Orphan Biovitrum; Celgene; Yakult Honsha; Amgen; Coherus Biosciences; FibroGen; Puma Biotechnology; Seagen; Relay Therapeutics; Daiichi Sankyo Europe; European Society for Medical Oncology; Agios Pharmaceuticals; Veracyte; Foundation Medicine; GlaxoSmithKline; Advanced Accelerator Applications; BeiGene; PharmaMar; Array BioPharma; Nihon Medi-Physics; Clovis Oncology; Genentech; AstraZeneca; Novocure; Natera; Regeneron Pharmaceuticals; G1 Therapeutics; Lantheus Medical Imaging; Merck KGaA; Gilead Sciences; Taiho Pharmaceutical; Sumitomo Dainippon Pharma Oncology; Ipsen; Pancreatic Cancer Action Network; Mirati Therapeutics; Handok; F. Hoffmann-La Roche; Eisai; National Cancer Institute; Fondazione Beretta; Incyte; Servier; Halozyme; Exelixis; Apollomics; Sanofi; Miyarisan Pharmaceutical; Aptitude Health; Eli Lilly and Company; Bristol-Myers Squibb; Yuhan; Spectrum Pharmaceuticals; Pfizer","keywords":"Trastuzumab; Oncology; Metastatic breast cancer; Breast cancer; Medicine; Internal medicine; Clinical trial; Cancer; Cancer research","routes":{"ca_aff":false,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":true},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.001551877,0.001602835,0.00174912,0.000417138,0.0002777769,0.001355783,0.0007357558,0.001348375,0.00440276],"category_scores_gemma":[0.001009973,0.0004231264,0.001100626,0.0005961932,0.0005245646,0.001237715,0.000537729,0.002475247,0.0007679475],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.001251677,"about_ca_system_score_gemma":0.001310342,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.001036164,"about_ca_topic_score_gemma":0.002592684,"domain_scores_codex":[0.9996244,0.0001535062,0.00001853225,0.00006628596,0.00004204192,0.00009511656],"domain_scores_gemma":[0.9995592,0.00005810399,0.00009611464,0.00003123065,0.00003405664,0.0002211443],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"randomized_trial","study_design_gemma":"randomized_trial","study_design_scores_codex":[0.8170015,0.01697449,0.004112166,0.001306038,0.001995214,0.0003795854,0.0002202158,0.003369539,0.01977954,0.001256127,0.01246778,0.1211378],"study_design_scores_gemma":[0.8911733,0.09216549,0.006997417,0.00009358548,0.0005958077,0.0004457868,0.00006257068,0.001969927,0.001278794,0.0005758164,0.004608378,0.00003322892],"study_design_candidate":"randomized_trial","study_design_consensus":"randomized_trial","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9845207,0.005285991,0.0005240131,0.001317048,0.0002674969,0.001889584,0.002606797,0.0001373433,0.003450976],"genre_scores_gemma":[0.9767606,0.005660911,0.001626526,0.002082801,0.0003344451,0.002515605,0.006796975,0.00005251648,0.004169594],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.00440276,"threshold_uncertainty_score":0.01472867,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.02580338968397959,"score_gpt":0.4717154380101767,"score_spread":0.4459120483261971,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}