{"id":"W4406536713","doi":"10.1002/gepi.22612","title":"A Novel Statistical Method for Unmasking Sex‐Specific Genomics Signatures in Complex Traits","year":2025,"lang":"en","type":"article","venue":"Genetic Epidemiology","topic":"Genetic Associations and Epidemiology","field":"Biochemistry, Genetics and Molecular Biology","cited_by":0,"is_retracted":false,"has_abstract":true,"ca_institutions":"Alberta Children's Hospital; University of Calgary; Université Laval","funders":"Natural Sciences and Engineering Research Council of Canada","keywords":"Computational biology; Biology; Genomics; Evolutionary biology; Genetics; Genome; Gene","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":["metaepi_narrow"],"consensus_categories":[],"category_scores_codex":[0.002369849,0.0003026355,0.0008075499,0.0001693187,0.000133583,0.000008113469,0.0003685742,0.0006346228,0.00004311827],"category_scores_gemma":[0.002512481,0.0003067668,0.000175762,0.0001738957,0.0001714574,0.000001572149,0.0001634393,0.0002335825,0.000004411575],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00008022895,"about_ca_system_score_gemma":0.0001840105,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00008062392,"about_ca_topic_score_gemma":0.0002347042,"domain_scores_codex":[0.996344,0.0008102749,0.001036251,0.0009163762,0.0000529925,0.0008401339],"domain_scores_gemma":[0.9972027,0.001968842,0.0002294414,0.0003935749,0.0000988915,0.0001065827],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"observational","study_design_scores_codex":[0.0003993138,0.0003794568,0.06278226,0.0001312725,0.0004659147,0.000004896585,0.000199734,0.08666096,0.4883873,0.04302206,0.1157117,0.2018551],"study_design_scores_gemma":[0.002340604,0.0003864423,0.5517086,0.00001676045,0.00005880825,0.00001967686,0.0001520074,0.04289685,0.001058899,0.03409748,0.366731,0.0005329231],"study_design_candidate":"observational","study_design_consensus":null,"genre_codex":"methods","genre_gemma":"methods","genre_scores_codex":[0.03790255,0.002618401,0.9558734,0.001743696,0.0002541508,0.0006183913,0.0001806591,0.00001657722,0.0007921846],"genre_scores_gemma":[0.1824122,0.0004275886,0.8109924,0.004642866,0.0002757793,0.0002325914,0.0003714599,0.00003262777,0.0006125339],"genre_candidate":"methods","genre_consensus":"methods","teacher_disagreement_score":0.4889263,"threshold_uncertainty_score":0.9999384,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.05287249980145674,"score_gpt":0.3664760927984859,"score_spread":0.3136035929970291,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}