{"id":"W4406552203","doi":"10.1186/s13195-025-01674-1","title":"Targeting early tau pathology: probiotic diet enhances cognitive function and reduces inflammation in a preclinical Alzheimer’s model","year":2025,"lang":"en","type":"article","venue":"Alzheimer s Research & Therapy","topic":"Gut microbiota and health","field":"Biochemistry, Genetics and Molecular Biology","cited_by":19,"is_retracted":false,"has_abstract":true,"ca_institutions":"Memorial University of Newfoundland","funders":"Canadian Institutes of Health Research","keywords":"Locus coeruleus; Neuroinflammation; Neurodegeneration; Tauopathy; Medicine; Neurology; Inflammation; Hippocampus; Neuroscience; Internal medicine; Pathology; Psychology; Disease; Central nervous system","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.001510245,0.0001690335,0.0002094956,0.000195595,0.0002160428,0.00006196613,0.0001626048,0.0002812037,0.00001057428],"category_scores_gemma":[0.0001606389,0.0001531533,0.00004818757,0.0002725151,0.0003099792,0.0000211961,0.000131242,0.0004235463,0.000009581293],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00001031511,"about_ca_system_score_gemma":0.0003198991,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0000742383,"about_ca_topic_score_gemma":0.00006867796,"domain_scores_codex":[0.9978663,0.0005377145,0.0003595028,0.0005878631,0.0001596581,0.0004890179],"domain_scores_gemma":[0.9992784,0.0001167361,0.00007383293,0.0001946264,0.000259081,0.00007738332],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.001960473,0.0001305673,0.002134452,0.00001440339,0.0003767355,0.00000241862,0.0005227875,0.0000287347,0.964725,0.000109496,0.0006033068,0.02939168],"study_design_scores_gemma":[0.005286144,0.005058737,0.07671828,0.0003135045,0.0002125925,0.000006297286,0.001109169,0.00210972,0.9008927,0.004542073,0.003058428,0.0006924152],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9607729,0.03657267,0.0003475912,0.0009296098,0.00009149234,0.0009933852,0.000009718898,0.00001546434,0.0002671123],"genre_scores_gemma":[0.9926393,0.006268119,0.0003561162,0.0002198595,0.0001333484,0.0001616368,0.0001032852,0.00001893659,0.00009940585],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.07458382,"threshold_uncertainty_score":0.6245412,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.1008677558555418,"score_gpt":0.4170457303892538,"score_spread":0.3161779745337119,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}