{"id":"W4406558664","doi":"10.1021/acs.jnatprod.4c01254","title":"Isolation of Antiplasmodial Oxazoles and Isoflavonoids from the Roots of <i>Oxytropis trichophysa</i> and Total Synthesis of Oxazole-type Alkaloids","year":2025,"lang":"en","type":"article","venue":"Journal of Natural Products","topic":"Traditional and Medicinal Uses of Annonaceae","field":"Biochemistry, Genetics and Molecular Biology","cited_by":2,"is_retracted":false,"has_abstract":true,"ca_institutions":"PROTO Manufacturing (Canada)","funders":"","keywords":"Isoflavonoid; Oxazole; Alkaloid; Chemistry; Stereochemistry; IC50; Biological activity; Flavonoid; Organic chemistry; Biochemistry; In vitro","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001559751,0.00009434757,0.0002471716,0.00006102834,0.00003245996,0.000005162974,0.0001081717,0.00006931778,0.000001154404],"category_scores_gemma":[0.0004949709,0.00006140921,0.00006207158,0.000131039,0.0001712502,0.0000167558,0.00004678365,0.000125937,5.735532e-8],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.000004672536,"about_ca_system_score_gemma":0.0001069075,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00002846294,"about_ca_topic_score_gemma":0.000006658181,"domain_scores_codex":[0.9992551,0.00003991526,0.0003486719,0.0001216788,0.0001585425,0.00007612126],"domain_scores_gemma":[0.9990354,0.0001096096,0.000332326,0.000112018,0.0003840162,0.0000266141],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.001005555,0.00006239182,0.004019617,0.00009105691,0.0001536347,9.86335e-7,0.00004212687,0.00001732074,0.9891478,0.00008312924,0.001716325,0.003660051],"study_design_scores_gemma":[0.0006401844,0.0004787858,0.254282,0.0001812381,0.0001225636,0.00002417913,0.00008063139,0.00001821372,0.7430283,0.0002181341,0.0008630179,0.00006269798],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9849551,0.0126979,0.00002174226,0.001824749,0.0003496874,0.00007466551,0.00003015647,9.558411e-7,0.0000449838],"genre_scores_gemma":[0.9972958,0.001530211,0.000760141,0.00006286104,0.0002894468,3.573203e-7,0.000009490949,0.000004610129,0.00004708194],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.2502624,"threshold_uncertainty_score":0.2504195,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.004651612761818914,"score_gpt":0.2170042282005745,"score_spread":0.2123526154387556,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}