{"id":"W4406559961","doi":"10.1016/j.omtn.2025.102457","title":"Advanced delivery systems for gene editing: A comprehensive review from the GenE-HumDi COST Action Working Group","year":2025,"lang":"en","type":"review","venue":"Molecular Therapy — Nucleic Acids","topic":"CRISPR and Genetic Engineering","field":"Biochemistry, Genetics and Molecular Biology","cited_by":48,"is_retracted":false,"has_abstract":true,"ca_institutions":"Institute of Infection and Immunity","funders":"Instituto de Salud Carlos III; Junta de Andalucía; Novo Nordisk Fonden; Ministarstvo Prosvete, Nauke i Tehnološkog Razvoja; European Research Council; Ministerio de Ciencia, Innovación y Universidades; Alexion Pharmaceuticals; Javna Agencija za Raziskovalno Dejavnost RS; Centre National de la Recherche Scientifique; Ministerio de Ciencia e Innovación; Novo Nordisk; H. Lundbeck A/S; Ikerbasque, Basque Foundation for Science; Lundbeckfonden; European Cooperation in Science and Technology; Innovationsfonden; Consejería de Salud y Consumo, Junta de Andalucía; Eusko Jaurlaritza","keywords":"Genome editing; Computational biology; Computer science; Gene delivery; Genome; Genetic enhancement; Biology; Action (physics); Gene; Genetics","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0007293793,0.001048378,0.001313507,0.002637312,0.0002114944,0.0008935083,0.0007799656,0.000948493,0.004047576],"category_scores_gemma":[0.0007035174,0.0003443862,0.0006141891,0.002018098,0.0002698936,0.001031263,0.000715601,0.002006266,0.003026717],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0005496386,"about_ca_system_score_gemma":0.00102706,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.000937591,"about_ca_topic_score_gemma":0.001644862,"domain_scores_codex":[0.9997792,0.0000349148,0.00003275279,0.00003993195,0.00009030217,0.00002289147],"domain_scores_gemma":[0.9997157,0.0001550662,0.00003542591,0.000008176325,0.0000655839,0.00002004127],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"design_other","study_design_gemma":"not_applicable","study_design_scores_codex":[0.0000806965,0.00006979066,0.00006976936,0.0304829,0.0001118784,0.0002092535,0.00006182255,0.0003994412,0.006033094,0.004221663,0.04458407,0.9136755],"study_design_scores_gemma":[0.00001831829,0.00008345438,0.0002522289,0.002829036,0.0001162869,0.0007658288,0.00002036321,0.00005682476,0.001382768,0.0006993796,0.9937541,0.00002144163],"study_design_candidate":"not_applicable","study_design_consensus":null,"genre_codex":"review","genre_gemma":"review","genre_scores_codex":[0.0001126373,0.997927,0.0004302259,0.0001765161,0.0002141288,0.00001471611,0.00005168256,0.00001617679,0.001056859],"genre_scores_gemma":[0.0004909316,0.9978755,0.000462984,0.0002371275,0.00006905873,0.000015858,0.00009971645,0.000004766607,0.0007441781],"genre_candidate":"review","genre_consensus":"review","teacher_disagreement_score":0.004047576,"threshold_uncertainty_score":0.01354051,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.03520205085088993,"score_gpt":0.3437855952266771,"score_spread":0.3085835443757872,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}