{"id":"W4406559961","doi":"10.1016/j.omtn.2025.102457","title":"Advanced delivery systems for gene editing: A comprehensive review from the GenE-HumDi COST Action Working Group","year":2025,"lang":"en","type":"review","venue":"Molecular Therapy — Nucleic Acids","topic":"CRISPR and Genetic Engineering","field":"Biochemistry, Genetics and Molecular Biology","cited_by":48,"is_retracted":false,"has_abstract":true,"ca_institutions":"Institute of Infection and Immunity","funders":"Instituto de Salud Carlos III; Junta de Andalucía; Novo Nordisk Fonden; Ministarstvo Prosvete, Nauke i Tehnološkog Razvoja; European Research Council; Ministerio de Ciencia, Innovación y Universidades; Alexion Pharmaceuticals; Javna Agencija za Raziskovalno Dejavnost RS; Centre National de la Recherche Scientifique; Ministerio de Ciencia e Innovación; Novo Nordisk; H. Lundbeck A/S; Ikerbasque, Basque Foundation for Science; Lundbeckfonden; European Cooperation in Science and Technology; Innovationsfonden; Consejería de Salud y Consumo, Junta de Andalucía; Eusko Jaurlaritza","keywords":"Genome editing; Computational biology; Computer science; Gene delivery; Genome; Genetic enhancement; Biology; Action (physics); Gene; Genetics","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":["metaepi_narrow"],"consensus_categories":[],"category_scores_codex":[0.0002506464,0.0007353673,0.001298614,0.00006790253,0.0002163076,0.0000947067,0.0007550481,0.0004339486,0.000009419012],"category_scores_gemma":[0.00006877185,0.0005838086,0.0009783437,0.0002661697,0.0000639856,0.000004986355,0.0001928015,0.0003400744,0.000008039129],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00007867556,"about_ca_system_score_gemma":0.0001358736,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00002229027,"about_ca_topic_score_gemma":0.000003487345,"domain_scores_codex":[0.997317,0.0002878738,0.000726434,0.0009197852,0.000256474,0.0004924681],"domain_scores_gemma":[0.9980706,0.0001434625,0.0003881923,0.00114282,0.0001548541,0.0001000974],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"design_other","study_design_gemma":"not_applicable","study_design_scores_codex":[0.00004381632,0.0000361386,0.000001472532,0.008171296,0.0009221744,0.00001232126,0.00001262781,0.0001956059,0.02389231,0.00001162048,0.002223494,0.9644771],"study_design_scores_gemma":[0.0005838367,0.0001204145,0.000002301087,0.01391951,0.0006121303,0.0000327455,0.00002751217,0.00004027979,0.003534141,0.000005479396,0.9805755,0.0005461574],"study_design_candidate":"not_applicable","study_design_consensus":null,"genre_codex":"review","genre_gemma":"review","genre_scores_codex":[0.0002771165,0.953536,0.04072954,0.000047356,0.001406959,0.003683357,0.0002266466,0.0000507644,0.00004229816],"genre_scores_gemma":[0.000184348,0.9921805,0.001192408,0.0009796929,0.001088661,0.001353118,0.002768001,0.0001596265,0.0000936092],"genre_candidate":"review","genre_consensus":"review","teacher_disagreement_score":0.978352,"threshold_uncertainty_score":0.9996613,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.03520205085088993,"score_gpt":0.3437855952266771,"score_spread":0.3085835443757872,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}