{"id":"W4406560916","doi":"10.1016/j.mex.2025.103177","title":"A method for siRNA-mediated knockdown of target genes in RA-induced neurogenesis using P19 cells","year":2025,"lang":"en","type":"article","venue":"MethodsX","topic":"RNA Interference and Gene Delivery","field":"Biochemistry, Genetics and Molecular Biology","cited_by":1,"is_retracted":false,"has_abstract":true,"ca_institutions":"","funders":"Institute of Genetics; Narodowe Centrum Nauki","keywords":"Neurogenesis; Gene knockdown; Gene; Cell biology; Biology; Genetics","routes":{"ca_aff":false,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":true},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0009121947,0.001123982,0.0006426867,0.001250711,0.00102777,0.0004455349,0.0007739455,0.0009915843,0.002840692],"category_scores_gemma":[0.0004490787,0.0006623075,0.001087345,0.0006227689,0.000463066,0.000518819,0.0005521444,0.001791378,0.003321896],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0004181176,"about_ca_system_score_gemma":0.0008264494,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0009269884,"about_ca_topic_score_gemma":0.002256889,"domain_scores_codex":[0.9988232,0.0001458335,0.000190964,0.0002873385,0.0004608308,0.00009182146],"domain_scores_gemma":[0.9996449,0.00007538743,0.00006951318,0.00009356109,0.00008650477,0.00003013415],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00002633332,0.00003577091,0.00007764484,0.0002023318,0.00001576896,0.0001658796,0.00005314709,0.00008739925,0.9900234,0.0003362742,0.0004893516,0.0084866],"study_design_scores_gemma":[0.00003258573,0.0002225107,0.0008726371,0.00003241791,0.00005795246,0.0009814393,0.00001654161,0.0007767074,0.959648,0.0001359493,0.03719565,0.00002767969],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"methods","genre_gemma":"methods","genre_scores_codex":[0.09427003,0.008724364,0.8650184,0.0007434151,0.001171388,0.005408022,0.004115941,0.003810404,0.01673815],"genre_scores_gemma":[0.2262648,0.01124676,0.7083768,0.0007544921,0.0001728764,0.01167949,0.009664709,0.001001343,0.03083868],"genre_candidate":"methods","genre_consensus":"methods","teacher_disagreement_score":0.002840692,"threshold_uncertainty_score":0.009503067,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.03246757693107697,"score_gpt":0.3628980787591753,"score_spread":0.3304305018280984,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}