{"id":"W4406580050","doi":"10.1016/j.jcyt.2025.01.005","title":"ISCT MSC committee statement on the US FDA approval of allogenic bone-marrow mesenchymal stromal cells","year":2025,"lang":"en","type":"article","venue":"Cytotherapy","topic":"Mesenchymal stem cell research","field":"Medicine","cited_by":40,"is_retracted":false,"has_abstract":false,"ca_institutions":"Toronto Rehabilitation Institute; University Health Network; Ottawa Hospital","funders":"","keywords":"Mesenchymal stem cell; Medicine; Bone marrow; Statement (logic); Stromal cell; Internal medicine; Pathology; Political science; Law","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":["insufficient_payload"],"consensus_categories":[],"category_scores_codex":[0.001166893,0.0002822264,0.0005362327,0.0002132735,0.0001436961,0.00003502904,0.0004061438,0.000135518,0.001953199],"category_scores_gemma":[0.00007360973,0.0001821292,0.0002575969,0.0004591384,0.0002759655,0.00004048558,0.00009390746,0.0004883325,0.0001221694],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0001908953,"about_ca_system_score_gemma":0.0003849006,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0001891538,"about_ca_topic_score_gemma":0.00002988753,"domain_scores_codex":[0.9971737,0.000312987,0.0005916056,0.0004352667,0.0009076502,0.000578814],"domain_scores_gemma":[0.998096,0.0004796562,0.0001481652,0.000961461,0.0001606174,0.0001540415],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.002091952,0.0009095643,0.01071054,0.0003195919,0.0007177581,0.0001154377,0.0005668949,0.00008030388,0.8973823,0.006421157,0.0724815,0.008202959],"study_design_scores_gemma":[0.005396691,0.002550916,0.01118125,0.0003254368,0.00009680093,0.00001800081,0.0005804839,0.0009638279,0.7774305,0.0005463555,0.200578,0.0003317479],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9608298,0.001041132,0.0002472778,0.006486151,0.0002639801,0.00155659,0.00002791243,0.00004914892,0.02949801],"genre_scores_gemma":[0.9772874,0.0003437446,0.0004251553,0.001849942,0.0001212489,0.00009589559,0.00001384511,0.00004197209,0.01982087],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.1280965,"threshold_uncertainty_score":0.9989591,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.02794839455077045,"score_gpt":0.3183486611563165,"score_spread":0.290400266605546,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}