{"id":"W4406586876","doi":"10.1101/2025.01.18.633737","title":"Nucleoplasmic Lamin A/C controls replication fork restart upon stress by modulating local H3K9me3 and ADP-ribosylation levels","year":2025,"lang":"en","type":"preprint","venue":"bioRxiv (Cold Spring Harbor Laboratory)","topic":"Nuclear Structure and Function","field":"Biochemistry, Genetics and Molecular Biology","cited_by":1,"is_retracted":false,"has_abstract":true,"ca_institutions":"Centre hospitalier universitaire de Québec","funders":"Universität Zürich; Oncode Institute; State Scholarships Foundation; Schweizerischer Nationalfonds zur Förderung der Wissenschaftlichen Forschung","keywords":"Lamin; Fork (system call); Replication (statistics); Cell biology; Biology; Genetics; Engineering; Structural engineering; Nucleus","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001039188,0.0002005046,0.0001346496,0.0001237888,0.0001762678,0.0003121887,0.0002097003,0.0002364185,0.001405984],"category_scores_gemma":[0.00007771028,0.000112929,0.0001850693,0.00006853152,0.00027728,0.0002054186,0.0002225682,0.0003124889,0.0003248484],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0002733052,"about_ca_system_score_gemma":0.0001322325,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0005986017,"about_ca_topic_score_gemma":0.0007167373,"domain_scores_codex":[0.9999206,0.000008306119,0.000005948685,0.00002686705,0.00001576579,0.00002247028],"domain_scores_gemma":[0.9998839,0.00000968512,0.0000465661,0.00001622534,0.00001290792,0.00003068295],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00005779502,0.000005805762,0.0001473611,0.000009681942,0.000002329286,0.000007134865,0.000003677399,0.00002470146,0.9993947,0.00002881972,0.000006725385,0.0003112319],"study_design_scores_gemma":[0.000007634925,0.0001242829,0.006592083,0.000003842997,0.000008885271,0.00005873683,0.00002414549,0.0007209477,0.9915175,0.00005814256,0.0008784285,0.000005245626],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9949782,0.0007896864,0.00285139,0.00005037396,0.0000151734,0.00001221415,0.0002084749,0.00008708382,0.001007264],"genre_scores_gemma":[0.9980018,0.0002031414,0.0007030361,0.00002031831,0.000003808305,0.00000944791,0.0001295209,0.00001244582,0.0009165997],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001405984,"threshold_uncertainty_score":0.004703462,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.007435901201933653,"score_gpt":0.2160747929552665,"score_spread":0.2086388917533329,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}