{"id":"W4406588954","doi":"10.1007/s40801-024-00478-3","title":"Mental Health-Related Disability Days and Costs Among Patients with Treatment-Resistant Depression Initiated on Esketamine Nasal Spray and Conventional Therapies in the USA","year":2025,"lang":"en","type":"article","venue":"Drugs - Real World Outcomes","topic":"Treatment of Major Depression","field":"Medicine","cited_by":1,"is_retracted":false,"has_abstract":true,"ca_institutions":"Group for Research in Decision Analysis","funders":"Janssen Scientific Affairs","keywords":"Nasal spray; Depression (economics); Treatment-resistant depression; Medicine; Mental health; Psychiatry; Nasal administration; Major depressive disorder; Pharmacology; Cognition","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0003346855,0.0001809234,0.000345419,0.0008325772,0.00033615,0.0006149524,0.0002390633,0.0002866004,0.001158095],"category_scores_gemma":[0.001460775,0.000181022,0.0005980731,0.001491129,0.0001616282,0.0004201046,0.0005093681,0.0006851125,0.000171393],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0008751921,"about_ca_system_score_gemma":0.0005179067,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.02339704,"about_ca_topic_score_gemma":0.04069509,"domain_scores_codex":[0.9995035,0.0001027888,0.0001113594,0.00007830638,0.0001189807,0.00008497523],"domain_scores_gemma":[0.9988083,0.0001052558,0.000758768,0.00002566458,0.0001187189,0.0001833144],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"observational","study_design_gemma":"observational","study_design_scores_codex":[0.0002245153,0.00007526569,0.9956671,0.0000277616,0.0001065113,0.00006878076,0.00006539177,0.00005138899,0.00005817324,0.00002363086,0.000992474,0.002638947],"study_design_scores_gemma":[0.0000246114,0.00007953375,0.9987307,0.0000250673,0.00004336647,0.0001906768,0.0002247268,0.0002468501,0.00002345068,0.00002024936,0.0003848904,0.000005766298],"study_design_candidate":"observational","study_design_consensus":"observational","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9965159,0.0003376259,0.00002668942,0.000119298,0.000006020709,0.00001792812,0.002506239,0.000002126914,0.0004681876],"genre_scores_gemma":[0.9964561,0.0003842759,0.00007158513,0.0001530007,0.00001934181,0.00003379337,0.00272168,0.000001467073,0.0001587226],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.02339704,"threshold_uncertainty_score":0.04652166,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01412784597760905,"score_gpt":0.2999420585609314,"score_spread":0.2858142125833223,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}