{"id":"W4406589008","doi":"10.1038/s41598-025-86115-7","title":"Selective toxicity of a novel antimicrobial peptide Acidocin 4356 against Pseudomonas aeruginosa and Acinetobacter baumannii in human cell-based in vitro infection models","year":2025,"lang":"en","type":"article","venue":"Scientific Reports","topic":"Antimicrobial Peptides and Activities","field":"Immunology and Microbiology","cited_by":3,"is_retracted":false,"has_abstract":true,"ca_institutions":"McGill University","funders":"National Institute for Genetic Engineering and Biotechnology","keywords":"Acinetobacter baumannii; Pseudomonas aeruginosa; Antimicrobial; Microbiology; In vitro; Biology; Pseudomonas; Toxicity; Acinetobacter; Antibiotics; Bacteria; Chemistry; Biochemistry","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0002687272,0.0003554668,0.0003932774,0.000211051,0.0001229381,0.0002543384,0.0001758547,0.0003005484,0.0004908557],"category_scores_gemma":[0.0001410888,0.0001253363,0.0002193226,0.0001971982,0.000142765,0.0001720058,0.0002372452,0.0003769233,0.0001281468],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0001481054,"about_ca_system_score_gemma":0.0001958776,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0008416197,"about_ca_topic_score_gemma":0.001097959,"domain_scores_codex":[0.9998037,0.00006208335,0.0000158093,0.00002387167,0.00006245337,0.00003208824],"domain_scores_gemma":[0.9999299,0.00001809195,0.00001667754,0.000005094092,0.00001677565,0.00001344028],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0001013224,0.00004778427,0.00007412422,0.0000965451,0.000003618199,0.00006187566,0.00001366221,0.0001322905,0.9982147,0.00002019826,0.00003459971,0.001199482],"study_design_scores_gemma":[0.00002215615,0.003287936,0.002881309,0.0000182976,0.00002865032,0.00036685,0.00006015789,0.001550533,0.9898216,0.00003076168,0.001919971,0.00001182087],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9899554,0.005277916,0.003125684,0.0001236615,0.00003731777,0.00006858475,0.0003676291,0.00004256867,0.001001324],"genre_scores_gemma":[0.9911014,0.003452079,0.003893338,0.00006517789,0.00001484321,0.00007142488,0.0003604284,0.00000539396,0.00103582],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.0008416197,"threshold_uncertainty_score":0.00167346,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01114514972109794,"score_gpt":0.2355453549324739,"score_spread":0.224400205211376,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}