{"id":"W4406593080","doi":"10.1016/j.ygeno.2025.111001","title":"WDR26 depletion alters chromatin accessibility and gene expression profiles in mammalian cells","year":2025,"lang":"en","type":"article","venue":"Genomics","topic":"RNA Interference and Gene Delivery","field":"Biochemistry, Genetics and Molecular Biology","cited_by":2,"is_retracted":false,"has_abstract":true,"ca_institutions":"Children’s Health Research Institute; Western University","funders":"Natural Sciences and Engineering Research Council of Canada; Canadian Institutes of Health Research; Lawson Health Research Institute","keywords":"Biology; Chromatin; Gene expression; Gene; Genetics; Regulation of gene expression; Cell biology; ChIA-PET; Computational biology; Chromatin remodeling","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.00009461885,0.0001860694,0.0002429647,0.0002349807,0.0001558114,0.0003172253,0.000166211,0.0001973694,0.001160871],"category_scores_gemma":[0.00006452726,0.0001676902,0.0002230581,0.0002104048,0.0001886976,0.0001051202,0.0002007657,0.0003197232,0.0005332703],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0001826964,"about_ca_system_score_gemma":0.0001240307,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0007036304,"about_ca_topic_score_gemma":0.001107738,"domain_scores_codex":[0.9998639,0.00001161092,0.00001273703,0.00006165489,0.00002783605,0.00002218606],"domain_scores_gemma":[0.9999208,0.00001597109,0.00002298881,0.00001513685,0.000006322423,0.00001872367],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00002738369,0.000005028058,0.000137685,0.000008917995,0.000002550388,0.00001818116,0.000008475835,0.00001962879,0.9994671,0.00002037865,0.00001571734,0.0002690207],"study_design_scores_gemma":[0.000007446711,0.0001152709,0.01872623,0.000005838116,0.00001638874,0.0002072038,0.00005149528,0.0007022322,0.9770487,0.00004454688,0.003067371,0.000007191162],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9911408,0.0014632,0.003167998,0.00006402557,0.00002802327,0.000016743,0.002181823,0.0001632119,0.001774174],"genre_scores_gemma":[0.9851722,0.001214858,0.002719614,0.0001180431,0.000009508772,0.0000389799,0.004719162,0.00007322782,0.005934501],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001160871,"threshold_uncertainty_score":0.003883481,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.008300919838516668,"score_gpt":0.247169306605372,"score_spread":0.2388683867668554,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}