{"id":"W4406593080","doi":"10.1016/j.ygeno.2025.111001","title":"WDR26 depletion alters chromatin accessibility and gene expression profiles in mammalian cells","year":2025,"lang":"en","type":"article","venue":"Genomics","topic":"RNA Interference and Gene Delivery","field":"Biochemistry, Genetics and Molecular Biology","cited_by":2,"is_retracted":false,"has_abstract":true,"ca_institutions":"Children’s Health Research Institute; Western University","funders":"Natural Sciences and Engineering Research Council of Canada; Canadian Institutes of Health Research; Lawson Health Research Institute","keywords":"Biology; Chromatin; Gene expression; Gene; Genetics; Regulation of gene expression; Cell biology; ChIA-PET; Computational biology; Chromatin remodeling","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001219372,0.00009803507,0.00009631653,0.00004680859,0.0000401584,0.00002759596,0.0001259079,0.0001089697,0.000009267679],"category_scores_gemma":[0.00001363621,0.00009548794,0.0000292106,0.00004636064,0.00003800702,0.000004730968,0.0001407588,0.00005305342,0.00000467082],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00002464447,"about_ca_system_score_gemma":0.00005190177,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00003758498,"about_ca_topic_score_gemma":0.00006438655,"domain_scores_codex":[0.9993057,0.00003949724,0.0001755739,0.0003009964,0.00003547435,0.0001427278],"domain_scores_gemma":[0.9996669,0.000005096638,0.00004481401,0.0002296475,0.00002308327,0.00003043444],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00006063032,0.00002239774,0.009512101,0.00002824245,0.00000560631,0.000001263794,0.00004822417,0.00004448135,0.9867991,0.00000444342,0.0006531842,0.002820375],"study_design_scores_gemma":[0.0002685474,0.00004925704,0.02654743,0.00002128677,0.00000451678,0.000001290879,0.00008234067,0.0001118016,0.9711331,0.0001105184,0.001573543,0.00009638599],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9977663,0.0005850256,0.0009638508,0.00007361286,0.0001302746,0.0001713361,0.00001682623,0.000005564948,0.0002872219],"genre_scores_gemma":[0.9971673,0.0003255676,0.001854797,0.0002214908,0.00005454192,0.00001919709,0.00007117091,0.000006881097,0.0002790132],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.01703533,"threshold_uncertainty_score":0.3893885,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.008300919838516668,"score_gpt":0.247169306605372,"score_spread":0.2388683867668554,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}