{"id":"W4406599402","doi":"10.1093/nar/gkae1320","title":"Single-nucleotide-resolution genomic maps of <i>O</i> 6-methylguanine from the glioblastoma drug temozolomide","year":2025,"lang":"en","type":"article","venue":"Nucleic Acids Research","topic":"Cancer Genomics and Diagnostics","field":"Biochemistry, Genetics and Molecular Biology","cited_by":4,"is_retracted":false,"has_abstract":true,"ca_institutions":"McGill University","funders":"Functional Genomics Center Zurich; Schweizerischer Nationalfonds zur Förderung der Wissenschaftlichen Forschung; National Science Foundation","keywords":"Biology; Temozolomide; DNA repair; Context (archaeology); Genome instability; Genetics; Methyltransferase; O-6-methylguanine-DNA methyltransferase; Chromatin; genomic DNA; DNA damage; DNA; Computational biology; Molecular biology; Cancer research; Glioma; Methylation","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0000605747,0.0001772053,0.0002014409,0.000447204,0.0002356123,0.0002540188,0.0002082749,0.0002821774,0.001466965],"category_scores_gemma":[0.0002334869,0.0002086038,0.0003098607,0.0004615427,0.00009473559,0.0001405373,0.0002240185,0.00039781,0.0005355944],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0002146103,"about_ca_system_score_gemma":0.000213861,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.003019858,"about_ca_topic_score_gemma":0.007166144,"domain_scores_codex":[0.9999552,0.000002573204,0.00000231115,0.00001660397,0.00001552411,0.000007911965],"domain_scores_gemma":[0.9998482,0.00002795853,0.00004303263,0.00002010084,0.00003989634,0.00002067986],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0001110047,0.0000130344,0.002387678,0.0001389049,0.00002728056,0.00008207583,0.0000423878,0.0009135031,0.9900123,0.0002386927,0.0004291413,0.005603927],"study_design_scores_gemma":[0.00003070669,0.0001905912,0.2486815,0.00004322002,0.0001721454,0.000656035,0.0002345239,0.01761208,0.7043003,0.001069581,0.02696917,0.0000401279],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9458194,0.002326938,0.03054095,0.0002472496,0.00006879761,0.00003437298,0.01410853,0.001013034,0.005840715],"genre_scores_gemma":[0.9236851,0.001401958,0.04510965,0.0002358521,0.0000275962,0.00006616922,0.0255169,0.000317349,0.003639459],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.003019858,"threshold_uncertainty_score":0.006004572,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01777004551071966,"score_gpt":0.2899862773106848,"score_spread":0.2722162317999651,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}