{"id":"W4406602299","doi":"10.1016/j.jcyt.2025.01.006","title":"Acute respiratory distress vs healthy lung environments differently affect mesenchymal stromal cell extracellular vesicle miRNAs","year":2025,"lang":"en","type":"article","venue":"Cytotherapy","topic":"Extracellular vesicles in disease","field":"Biochemistry, Genetics and Molecular Biology","cited_by":3,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of Manitoba; University of British Columbia; University of Toronto; St. Michael's Hospital","funders":"National Heart, Lung, and Blood Institute; Medical Research Council; Natural Sciences and Engineering Research Council of Canada; National Institute of Biomedical Imaging and Bioengineering; Canadian Institutes of Health Research; Larner College of Medicine, University of Vermont; National Institutes of Health; Alfred Österlunds Stiftelse; Fundação Carlos Chagas Filho de Amparo à Pesquisa do Estado do Rio de Janeiro; University of Minnesota; Science Foundation Ireland; Irish Research Council; Pakistan Association Of Cognitive Behavior Therapists; Medicinska Fakulteten, Lunds Universitet; Hjärt-Lungfonden; Kungliga Fysiografiska Sällskapet i Lund; Cystic Fibrosis Foundation; U.S. Department of Defense; University of Vermont; Magnus Bergvalls Stiftelse; National Institute of Diabetes and Digestive and Kidney Diseases; Lunds Universitet; University of Toronto; Cook Family Foundation","keywords":"Extracellular vesicle; Stromal cell; Mesenchymal stem cell; Microvesicles; Extracellular vesicles; Affect (linguistics); microRNA; Extracellular; Acute respiratory distress; Respiratory system; Medicine; Lung; Respiratory distress; Cell; Cell biology; Biology; Internal medicine; Psychology; Anesthesia; Genetics; Gene","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":["metaepi_narrow"],"consensus_categories":[],"category_scores_codex":[0.000195665,0.0003953677,0.0003042347,0.00008318599,0.0002155279,0.0000639208,0.0005489157,0.0002723073,0.0001014701],"category_scores_gemma":[0.00001580686,0.0004046903,0.000248588,0.0001303917,0.000200146,0.00001203325,0.0001556427,0.0002200424,0.00002868236],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0001065691,"about_ca_system_score_gemma":0.0001166708,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00000595125,"about_ca_topic_score_gemma":0.000005272865,"domain_scores_codex":[0.9976877,0.0002628406,0.0003941145,0.0007911396,0.0002739347,0.0005902963],"domain_scores_gemma":[0.9985378,0.00002922249,0.0001557323,0.001010483,0.00002107739,0.0002456759],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0009733202,0.0005074356,0.0187959,0.00006681273,0.0001955867,0.00005317333,0.00003592116,0.00002281866,0.9736453,0.000146691,0.00363998,0.001917089],"study_design_scores_gemma":[0.003466821,0.0006754577,0.02500822,0.00003652932,0.0001022848,0.000004021967,0.00006246493,0.0001590547,0.9275965,0.00007596023,0.04231083,0.0005018521],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9749835,0.01538971,0.007603501,0.0001843553,0.0003158389,0.0005688808,0.0001356369,0.00003904172,0.0007795257],"genre_scores_gemma":[0.9916722,0.0005458175,0.0004789353,0.0009909682,0.0002320026,0.00009119816,0.0001631246,0.00007450173,0.005751292],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.04604877,"threshold_uncertainty_score":0.9998405,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.006524216235683772,"score_gpt":0.2702464182743485,"score_spread":0.2637222020386648,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}