{"id":"W4406605792","doi":"10.1055/s-0044-1801037","title":"Insufficient control of cholestatic pruritus in primary biliary cholangitis (PBC) with current therapies: baseline data from the ongoing Phase 3 GLISTEN (Global Linerixibat Itch STudy of Efficacy and safety iN PBC) trial","year":2025,"lang":"en","type":"article","venue":"Zeitschrift für Gastroenterologie","topic":"Liver Diseases and Immunity","field":"Medicine","cited_by":0,"is_retracted":false,"has_abstract":false,"ca_institutions":"University of Toronto","funders":"","keywords":"Medicine; Internal medicine; Baseline (sea); Gastroenterology","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.003727334,0.0004584577,0.002217716,0.0001842662,0.00026413,0.001022023,0.0004117368,0.0008278658,0.002745687],"category_scores_gemma":[0.003718807,0.0002121035,0.00159837,0.0004123641,0.0007086385,0.001156999,0.0003717365,0.002066741,0.0003796228],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0006728399,"about_ca_system_score_gemma":0.000567811,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0007124881,"about_ca_topic_score_gemma":0.001487872,"domain_scores_codex":[0.9986159,0.0007932135,0.0001073434,0.0001294569,0.000159564,0.0001945651],"domain_scores_gemma":[0.9968922,0.001493536,0.0007765154,0.0002148788,0.0001525661,0.0004703672],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"randomized_trial","study_design_gemma":"randomized_trial","study_design_scores_codex":[0.6562495,0.003547125,0.04868367,0.004000256,0.008144515,0.0002193316,0.0002653193,0.00107398,0.01040045,0.0004888601,0.004865652,0.2620614],"study_design_scores_gemma":[0.3546777,0.2165869,0.3981029,0.0008144019,0.008102336,0.001447236,0.0002981887,0.001711076,0.003840511,0.00158662,0.01273317,0.0000989495],"study_design_candidate":"randomized_trial","study_design_consensus":"randomized_trial","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9546284,0.03836669,0.00048529,0.00139681,0.0001784824,0.00038384,0.001572406,0.00008057534,0.002907533],"genre_scores_gemma":[0.9927779,0.004005141,0.0002778584,0.0009611335,0.000154549,0.0001366412,0.001355667,0.00001454008,0.0003164479],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.003727334,"threshold_uncertainty_score":0.01971227,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.03580828521804347,"score_gpt":0.3467960111493544,"score_spread":0.3109877259313109,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}