{"id":"W4406606700","doi":"10.1016/j.tranon.2025.102284","title":"Disitamab vedotin in preclinical models of HER2-positive breast and gastric cancers resistant to trastuzumab emtansine and trastuzumab deruxtecan","year":2025,"lang":"en","type":"article","venue":"Translational Oncology","topic":"HER2/EGFR in Cancer Research","field":"Medicine","cited_by":9,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of Ottawa","funders":"Syöpäjärjestöt; Sigrid Juséliuksen Säätiö; Jane ja Aatos Erkon Säätiö; Biocenter Finland; Helsingin Yliopisto","keywords":"Trastuzumab; Trastuzumab emtansine; Medicine; Oncology; Internal medicine; Breast cancer; Cancer","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0004577556,0.0008242045,0.0006364644,0.0005315244,0.0002227181,0.0003367203,0.0005188756,0.0004219943,0.001398839],"category_scores_gemma":[0.0001827492,0.0002734436,0.0003636443,0.0003916208,0.0002546973,0.0003713525,0.0001442795,0.001222395,0.0002927087],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0008455278,"about_ca_system_score_gemma":0.0005863053,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.002551212,"about_ca_topic_score_gemma":0.003999277,"domain_scores_codex":[0.9997575,0.00005107527,0.00001867799,0.00003717623,0.00005665634,0.00007898291],"domain_scores_gemma":[0.9998375,0.00002901039,0.00004004236,0.00002332503,0.00001934487,0.00005072595],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.004744962,0.004405798,0.0008101559,0.0002097215,0.00007285884,0.0001747628,0.0001134993,0.001635731,0.9779046,0.0003258028,0.0007181205,0.008884085],"study_design_scores_gemma":[0.001162885,0.04403166,0.006712559,0.00001746083,0.0001362368,0.0006552442,0.00007501488,0.004330076,0.9372624,0.00009036965,0.005510253,0.00001585874],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9952934,0.001498314,0.000736351,0.00012922,0.00004700563,0.0001895711,0.0006482052,0.00008673472,0.001371262],"genre_scores_gemma":[0.9911849,0.001695604,0.001818877,0.00006161771,0.00002223157,0.000298961,0.001397173,0.00002600259,0.003494653],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.002551212,"threshold_uncertainty_score":0.006134689,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.04665332703341679,"score_gpt":0.4109207860228478,"score_spread":0.364267458989431,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}