{"id":"W4406606896","doi":"10.1016/s2213-8587(24)00304-8","title":"Semaglutide in obesity-related heart failure with preserved ejection fraction and type 2 diabetes across baseline HbA1c levels (STEP-HFpEF DM): a prespecified analysis of heart failure and metabolic outcomes from a randomised, placebo-controlled trial","year":2025,"lang":"en","type":"article","venue":"The Lancet Diabetes & Endocrinology","topic":"Diabetes Treatment and Management","field":"Medicine","cited_by":19,"is_retracted":false,"has_abstract":false,"ca_institutions":"University of Toronto; St. Michael's Hospital","funders":"American Regent; Vifor Pharma; Horizon Therapeutics; Impulse Dynamics; National Institutes of Health; Regeneron Pharmaceuticals; Dexcom; ReCor Medical; Astellas Pharma; Cytokinetics; Prothena; AstraZeneca; Amarin Corporation; Boston Scientific Corporation; Eli Lilly and Company; U.S. Department of Defense; Sanofi; HLS Therapeutics; LivaNova; GlaxoSmithKline; CSL Behring; Bristol-Myers Squibb; Edwards Lifesciences; Amgen; Moderna; Pfizer; Tenax Therapeutics; Esperion Therapeutics; Alnylam Pharmaceuticals; Novo Nordisk; MyoKardia; Gilead Sciences","keywords":"Medicine; Heart failure; Heart failure with preserved ejection fraction; Ejection fraction; Internal medicine; Cardiology; Semaglutide; Obesity; Type 2 diabetes; Baseline (sea); Diabetes mellitus; Endocrinology","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.002305237,0.001935515,0.005247158,0.0004349306,0.0003859116,0.001435873,0.0008364458,0.001708532,0.004365487],"category_scores_gemma":[0.00213404,0.0007525807,0.004127328,0.0005118928,0.0011326,0.001373963,0.0005975586,0.002725876,0.0005618752],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0007109959,"about_ca_system_score_gemma":0.0006324273,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00141138,"about_ca_topic_score_gemma":0.003743492,"domain_scores_codex":[0.9989927,0.0005409224,0.00008797374,0.0001715726,0.00006589765,0.0001409313],"domain_scores_gemma":[0.9989875,0.0004103346,0.0002316183,0.0000990391,0.00005647083,0.000215015],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"randomized_trial","study_design_gemma":"randomized_trial","study_design_scores_codex":[0.987288,0.0007373614,0.001139163,0.000672664,0.003814685,0.00003275743,0.00002587671,0.0001881543,0.0008458721,0.00006882777,0.0002490133,0.004937635],"study_design_scores_gemma":[0.9653025,0.02317534,0.005871685,0.00008256448,0.004440676,0.00003667426,0.0000406322,0.0003241315,0.0002108925,0.0001681314,0.0003239473,0.00002275659],"study_design_candidate":"randomized_trial","study_design_consensus":"randomized_trial","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9840826,0.01175802,0.0005290635,0.0004452612,0.0006138248,0.0005965919,0.0006581342,0.0001051803,0.00121146],"genre_scores_gemma":[0.9924213,0.003586588,0.0006317929,0.0006937237,0.0004823898,0.000463166,0.0006593364,0.00001582964,0.001045936],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.005247158,"threshold_uncertainty_score":0.01460397,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01747682130933467,"score_gpt":0.2834660659037371,"score_spread":0.2659892445944024,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}