{"id":"W4406615869","doi":"10.3390/curroncol32010052","title":"Real-World Experience with CDK4/6 Inhibitors in the First-Line Palliative Setting for HR+/HER2− Advanced Breast Cancer","year":2025,"lang":"en","type":"article","venue":"Current Oncology","topic":"Advanced Breast Cancer Therapies","field":"Medicine","cited_by":5,"is_retracted":false,"has_abstract":true,"ca_institutions":"Windsor Regional Hospital; Western University","funders":"","keywords":"Palbociclib; Medicine; Internal medicine; Oncology; Metastatic breast cancer; Breast cancer; Cancer; Proportional hazards model; Exemestane; Progression-free survival; Cohort; Aromatase; Overall survival","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":true,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0002171184,0.000260945,0.0004840699,0.0001875011,0.0001540547,0.00001157489,0.00021806,0.00007507698,0.00004548973],"category_scores_gemma":[0.00006633165,0.0001719284,0.00007546205,0.000757703,0.0002777974,0.0001225433,0.00005512464,0.0003921205,0.00000209298],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0009404831,"about_ca_system_score_gemma":0.0004751621,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0001436027,"about_ca_topic_score_gemma":0.004511948,"domain_scores_codex":[0.9983751,0.0000688198,0.0004022949,0.0004770544,0.0001967659,0.0004799747],"domain_scores_gemma":[0.9987125,0.0004586296,0.0002147679,0.0003216477,0.000228058,0.00006441838],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"design_other","study_design_gemma":"not_applicable","study_design_scores_codex":[0.003762428,0.0006489786,0.3308854,0.0003823713,0.00008819668,0.0000221894,0.009362566,0.0004770284,0.0003476739,0.001109876,0.0007969887,0.6521163],"study_design_scores_gemma":[0.01279916,0.0009016457,0.4263126,0.002645458,0.0001661231,0.00003724677,0.006935491,0.0006890636,0.001339944,0.0009950505,0.5467493,0.0004289535],"study_design_candidate":"observational","study_design_consensus":null,"genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9227068,0.006415101,0.005590154,0.05406389,0.002927469,0.004834649,0.000177096,0.0001997425,0.00308506],"genre_scores_gemma":[0.9920281,0.0006129648,0.001555994,0.001644048,0.0005475066,0.003237815,0.00003245138,0.00003337033,0.0003077334],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.6516873,"threshold_uncertainty_score":0.7011036,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.05844413702398454,"score_gpt":0.4453862597411429,"score_spread":0.3869421227171584,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}