{"id":"W4406617825","doi":"10.1016/j.xcrp.2024.102399","title":"An injectable hydrogel for synergistic therapy in colorectal cancer by targeting glutathione","year":2025,"lang":"en","type":"article","venue":"Cell Reports Physical Science","topic":"Sulfur Compounds in Biology","field":"Biochemistry, Genetics and Molecular Biology","cited_by":7,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of British Columbia","funders":"Liaoning Revitalization Talents Program; Key Research Project of Liaoning; China Medical University; Natural Science Foundation of Liaoning Province","keywords":"Colorectal cancer; Glutathione; Medicine; Cancer therapy; Cancer research; Cancer; Oncology; Pharmacology; Internal medicine; Chemistry; Biochemistry","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.00008679669,0.0002472576,0.0001047968,0.0001318165,0.00007014937,0.0001075468,0.00009984716,0.0001916472,0.0007671071],"category_scores_gemma":[0.0000526892,0.00006276776,0.0001435814,0.00007007021,0.00008486314,0.0001488941,0.000113934,0.0002317854,0.0001521509],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0001424263,"about_ca_system_score_gemma":0.0001082032,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0002284914,"about_ca_topic_score_gemma":0.0005213147,"domain_scores_codex":[0.9999716,0.00000493053,0.000002114556,0.000007608857,0.000008264742,0.000005482932],"domain_scores_gemma":[0.9999697,0.000005122542,0.00001214551,0.000001890814,0.000002775479,0.000008405404],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00005907654,0.00002500194,0.00006724912,0.0000770987,0.000006356368,0.00005172896,0.000007737075,0.00009513285,0.9947863,0.0001054749,0.00009179172,0.004627133],"study_design_scores_gemma":[0.00001639189,0.0004073732,0.0004972069,0.000006990679,0.00001676956,0.0001648425,0.000005722884,0.0009039927,0.9938637,0.00001894526,0.004093218,0.000004893675],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9656817,0.009413983,0.01960328,0.0004478796,0.0002131502,0.0001135804,0.0004248642,0.0002789114,0.003822599],"genre_scores_gemma":[0.9825346,0.002363193,0.01160751,0.0001527272,0.00003156872,0.00005582819,0.0001306724,0.00001934573,0.003104633],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.0007671071,"threshold_uncertainty_score":0.002566218,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.006523491399649434,"score_gpt":0.2892899615694914,"score_spread":0.282766470169842,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}