{"id":"W4406632374","doi":"10.1016/j.brainresbull.2025.111217","title":"GABAB receptors regulate the neural stem cell potential of Pkd2l1+ cerebrospinal fluid-contacting neurons via the PI3K/Akt signaling pathway","year":2025,"lang":"en","type":"article","venue":"Brain Research Bulletin","topic":"Neurogenesis and neuroplasticity mechanisms","field":"Neuroscience","cited_by":2,"is_retracted":false,"has_abstract":true,"ca_institutions":"Hotchkiss Brain Institute; University of Calgary","funders":"National Natural Science Foundation of China","keywords":"GABAB receptor; Cerebrospinal fluid; Neuroscience; PI3K/AKT/mTOR pathway; Neural stem cell; Signal transduction; Receptor; Protein kinase B; Cell biology; Chemistry; Biology; Stem cell; GABAA receptor; Biochemistry","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":["sts"],"consensus_categories":[],"category_scores_codex":[0.002862787,0.0003536253,0.0003586727,0.0002913546,0.001806498,0.0003169676,0.001744028,0.000117881,0.0003858968],"category_scores_gemma":[0.001664392,0.0002305203,0.0002849134,0.001221682,0.0006296828,0.00007881065,0.0009667523,0.001304079,0.0001410301],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00005401393,"about_ca_system_score_gemma":0.0002024752,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0000892877,"about_ca_topic_score_gemma":0.000005290141,"domain_scores_codex":[0.991272,0.004284191,0.0007077491,0.001014349,0.001549574,0.001172095],"domain_scores_gemma":[0.9922779,0.006094216,0.0002450032,0.0009791863,0.0002331916,0.0001705324],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.000271935,0.0001264076,0.00002107174,0.0000674482,0.000007787913,0.0000938791,0.0001478116,0.0006549447,0.9870697,0.001633665,0.006418813,0.003486517],"study_design_scores_gemma":[0.0005327115,0.0004502832,0.0001908806,0.00006567367,0.00001545683,0.00004941363,0.0003273967,0.003023423,0.9736274,0.0001320647,0.02139825,0.0001870386],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9760551,0.0001127371,0.0009552345,0.01948574,0.001062142,0.001126251,0.00002360451,0.00009985884,0.001079297],"genre_scores_gemma":[0.9922698,0.000029486,0.00003409905,0.002140273,0.0001817065,0.00007034966,0.000001287083,0.00006699631,0.005206069],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.01734547,"threshold_uncertainty_score":0.999493,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.04652979025340156,"score_gpt":0.2950988262748654,"score_spread":0.2485690360214639,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}