{"id":"W4406640748","doi":"10.1038/s41398-025-03235-4","title":"Mitochondrial DNA variants and their impact on epigenetic and biological aging in young adulthood","year":2025,"lang":"en","type":"article","venue":"Translational Psychiatry","topic":"Mitochondrial Function and Pathology","field":"Biochemistry, Genetics and Molecular Biology","cited_by":6,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of Toronto; University of Saskatchewan; Centre for Addiction and Mental Health","funders":"Canadian Institutes of Health Research; Agentura Pro Zdravotnický Výzkum České Republiky; CIHR Skin Research Training Centre; Grantová Agentura České Republiky; Central European Institute of Technology; Government of Canada; Ministerstvo Školství, Mládeže a Tělovýchovy; Natural Sciences and Engineering Research Council of Canada; Centre for Addiction and Mental Health Foundation","keywords":"Epigenetics; Mitochondrial DNA; Epigenesis; Genetics; Biological age; Young adult; DNA methylation; Schizophrenia (object-oriented programming); Cellular Aging; Biology; Medicine; DNA; Psychology; Psychiatry; Gerontology; Evolutionary biology; Gene; Telomere","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0004510556,0.0001878078,0.0001528963,0.0004656597,0.000208468,0.000297959,0.0001376672,0.0002341709,0.0008326755],"category_scores_gemma":[0.001619943,0.00009822642,0.0001717609,0.0003660652,0.0001668536,0.0002243415,0.0002532201,0.0001949432,0.00008577804],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0001714986,"about_ca_system_score_gemma":0.0001625013,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.003115584,"about_ca_topic_score_gemma":0.00633633,"domain_scores_codex":[0.9998498,0.00003416463,0.00001673637,0.00004546702,0.00002800538,0.0000257976],"domain_scores_gemma":[0.9993205,0.0001032595,0.0003583936,0.00003609719,0.00007454828,0.0001072495],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"observational","study_design_gemma":"observational","study_design_scores_codex":[0.0001957944,0.00003281693,0.9927006,0.00001648373,0.00007784479,0.00009512425,0.0001796494,0.00004495838,0.001180735,0.00008881256,0.00004793628,0.005339245],"study_design_scores_gemma":[0.000001730806,0.00009240274,0.9993207,0.000005320393,0.00001988341,0.0001143051,0.00006299944,0.00006465458,0.0001385214,0.00008937551,0.00008864549,0.000001492058],"study_design_candidate":"observational","study_design_consensus":"observational","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9988189,0.000641251,0.0001267189,0.00002557467,0.000004332332,0.000003261451,0.0001476482,0.000002045676,0.0002303161],"genre_scores_gemma":[0.9995178,0.0001610314,0.0001056646,0.00001048355,0.000003895479,0.000001957515,0.00006928806,6.058594e-7,0.0001292247],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.003115584,"threshold_uncertainty_score":0.00619489,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.009609748992596631,"score_gpt":0.2678393389855828,"score_spread":0.2582295899929861,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}