{"id":"W4406652401","doi":"10.1513/annalsats.202410-1070le","title":"Is There a Role for Lumacaftor/Ivacaftor in Young Children with Cystic Fibrosis?","year":2025,"lang":"en","type":"letter","venue":"Annals of the American Thoracic Society","topic":"Cystic Fibrosis Research Advances","field":"Medicine","cited_by":0,"is_retracted":false,"has_abstract":false,"ca_institutions":"University of Toronto; Hospital for Sick Children","funders":"","keywords":"Ivacaftor; Medicine; Cystic fibrosis; MEDLINE; Intensive care medicine; Cystic fibrosis transmembrane conductance regulator; Internal medicine","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.00117206,0.0003638796,0.0008523263,0.0005262059,0.002493924,0.001481563,0.0007435243,0.02345309,0.007877631],"category_scores_gemma":[0.01233659,0.000351207,0.0009794716,0.0003425726,0.001866948,0.002313803,0.0008017015,0.01629389,0.002658656],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.002504996,"about_ca_system_score_gemma":0.004782196,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00666061,"about_ca_topic_score_gemma":0.01438904,"domain_scores_codex":[0.9988348,0.0002880903,0.0001714748,0.0001194547,0.0003147683,0.0002714257],"domain_scores_gemma":[0.9945272,0.002085466,0.0005255665,0.0001151507,0.0006176651,0.002128923],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"not_applicable","study_design_gemma":"not_applicable","study_design_scores_codex":[0.0001764675,0.0001747509,0.02504797,0.0001748856,0.00005723245,0.03149983,0.0003758217,0.0001926768,0.0006454492,0.005539528,0.901657,0.03445834],"study_design_scores_gemma":[0.0005288728,0.0004762041,0.02181851,0.002362696,0.0001478,0.05701079,0.001843511,0.00080451,0.0005385047,0.01315003,0.9012166,0.0001018897],"study_design_candidate":"not_applicable","study_design_consensus":"not_applicable","genre_codex":"commentary","genre_gemma":"commentary","genre_scores_codex":[0.002678139,0.002762799,0.00008013985,0.9797624,0.009534872,0.00000774278,0.00003778112,0.00001972237,0.00511638],"genre_scores_gemma":[0.02920011,0.005919862,0.0005046263,0.8920132,0.06506656,0.00003981347,0.00008449422,0.00003262737,0.007138603],"genre_candidate":"commentary","genre_consensus":"commentary","teacher_disagreement_score":0.02345309,"threshold_uncertainty_score":0.02635324,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.03707246678016219,"score_gpt":0.3856763580089166,"score_spread":0.3486038912287545,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}