{"id":"W4406664644","doi":"10.1172/jci188016","title":"Mycobacterium tuberculosis resisters despite HIV exhibit activated T cells and macrophages in their pulmonary alveoli","year":2025,"lang":"en","type":"article","venue":"Journal of Clinical Investigation","topic":"Immune Cell Function and Interaction","field":"Immunology and Microbiology","cited_by":24,"is_retracted":false,"has_abstract":true,"ca_institutions":"McGill University; McGill University Health Centre","funders":"Faculty of Medicine and Health, University of Sydney; National Institute of Allergy and Infectious Diseases; Medical Research Council; National Institutes of Health; St. Giles Foundation; Universiteit Stellenbosch; Agence Nationale de Recherches sur le Sida et les Hépatites Virales; CHIST-ERA; National Center for Advancing Translational Sciences; Agence Nationale de la Recherche; South African Medical Research Council; Canadian Institutes of Health Research; Alliance de recherche numérique du Canada; McGill University Health Centre; McGill University; Institut des maladies génétiques Imagine","keywords":"Granulysin; CTL*; Cytotoxic T cell; Perforin; Mycobacterium tuberculosis; Immunology; Biology; Granzyme; Bronchoalveolar lavage; T cell; Ex vivo; Virology; Microbiology; CD8; Medicine; Immune system; Tuberculosis; In vitro; Lung; Pathology","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":true,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001177576,0.0002189027,0.0002107631,0.0002747382,0.0002837535,0.0003855805,0.0001126802,0.0002560506,0.002252751],"category_scores_gemma":[0.0002106098,0.0001697084,0.0001468485,0.0001416155,0.0001864836,0.0002150913,0.0002318714,0.0002809624,0.0004553459],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00006645726,"about_ca_system_score_gemma":0.00004619779,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0002342649,"about_ca_topic_score_gemma":0.000294623,"domain_scores_codex":[0.9998972,0.0000118007,0.000009466252,0.00002910433,0.00001385466,0.00003865015],"domain_scores_gemma":[0.9998658,0.00001781555,0.00004608441,0.00001965816,0.00001916637,0.00003142666],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"observational","study_design_scores_codex":[0.0007847433,0.0001322273,0.1518848,0.0001035029,0.00002989691,0.002772551,0.0005187101,0.00005667916,0.8325802,0.0001497727,0.0002275059,0.0107594],"study_design_scores_gemma":[0.00006075577,0.001513751,0.9017636,0.000041394,0.00007175565,0.01607677,0.001161973,0.0003300361,0.07370648,0.0003527581,0.004902688,0.00001812251],"study_design_candidate":"observational","study_design_consensus":null,"genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9990354,0.0003356348,0.0001228339,0.00002114307,0.000003395202,0.00001116466,0.0001094971,0.00000845695,0.0003524282],"genre_scores_gemma":[0.9986452,0.0001518985,0.0001983544,0.00004828741,0.00001596505,0.00002018224,0.0001988482,0.000004972686,0.000716255],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.002252751,"threshold_uncertainty_score":0.007536232,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.02679595442364356,"score_gpt":0.2988540074960211,"score_spread":0.2720580530723775,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}