{"id":"W4406665586","doi":"10.1158/1078-0432.ccr-24-2753","title":"Population Pharmacokinetics of Orvacabtagene Autoleucel, an Autologous BCMA-Directed Chimeric Antigen Receptor T-cell Product, in Patients with Relapsed/Refractory Multiple Myeloma","year":2025,"lang":"en","type":"article","venue":"Clinical Cancer Research","topic":"CAR-T cell therapy research","field":"Medicine","cited_by":9,"is_retracted":false,"has_abstract":true,"ca_institutions":"Aurinia (Canada)","funders":"","keywords":"Multiple myeloma; Cmax; Population; Medicine; Pharmacokinetics; Oncology; Immunology; Pharmacology; Internal medicine","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0008326644,0.000317343,0.0005785542,0.000116665,0.00009557646,0.0004015706,0.0002785106,0.0003254699,0.0003875995],"category_scores_gemma":[0.001636394,0.0002104899,0.0003962918,0.0001628205,0.0002086339,0.0004236854,0.0002259293,0.0006225568,0.00008849418],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0006000621,"about_ca_system_score_gemma":0.0004652097,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.001087349,"about_ca_topic_score_gemma":0.0008188745,"domain_scores_codex":[0.9996729,0.0001825728,0.00001185857,0.00005943925,0.00005152351,0.00002176873],"domain_scores_gemma":[0.9995394,0.0001968475,0.0001586373,0.00004453123,0.00001996508,0.00004065662],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"observational","study_design_gemma":"observational","study_design_scores_codex":[0.1174415,0.005800056,0.3180874,0.0004926799,0.002047546,0.0007979402,0.001077282,0.2334445,0.1231629,0.0009017615,0.001489391,0.1952571],"study_design_scores_gemma":[0.008944551,0.1715853,0.386975,0.00005395412,0.001766157,0.001768198,0.0004137948,0.373217,0.04805226,0.001211089,0.005893081,0.0001194688],"study_design_candidate":"observational","study_design_consensus":"observational","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9982706,0.0002573247,0.001169534,0.00002863532,0.000002003433,0.00003117873,0.00007071652,0.00001935876,0.0001505756],"genre_scores_gemma":[0.9992195,0.00009231473,0.0004384604,0.00003362976,0.000003529203,0.0000204551,0.000115741,0.000003853412,0.00007246322],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001087349,"threshold_uncertainty_score":0.004403591,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.08116083786380267,"score_gpt":0.4550818260549206,"score_spread":0.3739209881911179,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}