{"id":"W4406666623","doi":"10.7759/cureus.77781","title":"The Role of PET Detection of Biomarkers in Early Diagnosis, Progression, and Prognosis of Alzheimer’s Disease: A Systematic Review","year":2025,"lang":"en","type":"review","venue":"Cureus","topic":"Dementia and Cognitive Impairment Research","field":"Medicine","cited_by":4,"is_retracted":false,"has_abstract":true,"ca_institutions":"","funders":"","keywords":"Medicine; Disease; Pet imaging; Biomarker; Oncology; Positron emission tomography; Pathology; Internal medicine; Intensive care medicine; Radiology","routes":{"ca_aff":false,"ca_fund":false,"ca_venue":false,"about_ca":true,"invisible_to_affiliation_only":true},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.009663716,0.001856616,0.01182834,0.009492171,0.0006473168,0.002844039,0.001992128,0.002212515,0.003584801],"category_scores_gemma":[0.04255496,0.0009698772,0.01116729,0.008918301,0.0008573744,0.002538919,0.001360775,0.001194589,0.0003060434],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00299485,"about_ca_system_score_gemma":0.01043089,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.007537483,"about_ca_topic_score_gemma":0.01887299,"domain_scores_codex":[0.992713,0.002408744,0.002810748,0.0005873729,0.001267499,0.0002125286],"domain_scores_gemma":[0.9699522,0.02246451,0.004327877,0.0004270861,0.002585193,0.000243117],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"systematic_review","study_design_gemma":"systematic_review","study_design_scores_codex":[0.0002715138,0.00001223455,0.0008527148,0.9562381,0.01624716,0.00005904305,0.00008589025,0.00009503794,0.0001160376,0.0001127437,0.0007658622,0.02514371],"study_design_scores_gemma":[0.0003310546,0.0002199529,0.004714213,0.7706187,0.2120651,0.000306688,0.0001397667,0.0001744081,0.0001734294,0.0003383049,0.01086572,0.00005274075],"study_design_candidate":"systematic_review","study_design_consensus":"systematic_review","genre_codex":"review","genre_gemma":"review","genre_scores_codex":[0.000587016,0.9985632,0.0001048649,0.0001569942,0.00007536385,0.0001976633,0.0001950026,0.000005516785,0.0001142859],"genre_scores_gemma":[0.01146817,0.9866655,0.0005225583,0.0004265432,0.0001020085,0.0005301849,0.0001959,0.000005200756,0.00008382685],"genre_candidate":"review","genre_consensus":"review","teacher_disagreement_score":0.01182834,"threshold_uncertainty_score":0.05110723,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.02272896146322836,"score_gpt":0.3703319295568548,"score_spread":0.3476029680936265,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}