{"id":"W4406667181","doi":"10.1165/rcmb.2024-0251ma","title":"Improved Annotation of Asthma Gene Variants with Cell Type Deconvolution of Nasal and Lung Expression Quantitative Trait Loci","year":2025,"lang":"en","type":"review","venue":"American Journal of Respiratory Cell and Molecular Biology","topic":"Asthma and respiratory diseases","field":"Medicine","cited_by":4,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of Alberta; University of British Columbia; St. Paul's Hospital; Université Laval; Institut universitaire de cardiologie et de pneumologie de Québec","funders":"HORIZON EUROPE European Innovation Council","keywords":"Biology; Expression quantitative trait loci; Gene; Asthma; Deconvolution; Cell type; Quantitative trait locus; Trait; Gene expression; Computational biology; Genetics; Cell; Genotype; Immunology; Computer science; Algorithm","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.01162163,0.001019157,0.001848713,0.004010011,0.0006322382,0.002313665,0.001632578,0.0008661572,0.004419106],"category_scores_gemma":[0.01573821,0.0004931556,0.006752089,0.003466066,0.0004285892,0.0005873467,0.001732794,0.001387199,0.0006268426],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00055138,"about_ca_system_score_gemma":0.0009148102,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00524458,"about_ca_topic_score_gemma":0.008334108,"domain_scores_codex":[0.9927438,0.003134,0.0005813051,0.002335732,0.000851805,0.0003532422],"domain_scores_gemma":[0.9826367,0.01237237,0.001523426,0.00213618,0.001053021,0.0002782975],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"observational","study_design_gemma":"not_applicable","study_design_scores_codex":[0.002701893,0.0001802741,0.7134591,0.002157469,0.03194913,0.001476038,0.0006583987,0.01677976,0.1015727,0.002699347,0.003925778,0.1224401],"study_design_scores_gemma":[0.000924613,0.0007283073,0.7332969,0.0007615286,0.03928544,0.002378116,0.0005065507,0.1606531,0.0291666,0.01160474,0.02040452,0.0002896881],"study_design_candidate":"not_applicable","study_design_consensus":null,"genre_codex":"empirical","genre_gemma":"review","genre_scores_codex":[0.6235602,0.01082603,0.3386841,0.001070842,0.00033944,0.0002123458,0.02054591,0.002027205,0.002733801],"genre_scores_gemma":[0.9176119,0.0007657773,0.07018553,0.0005769469,0.0001036922,0.0001974284,0.008905472,0.0005439607,0.001109203],"genre_candidate":"review","genre_consensus":null,"teacher_disagreement_score":0.01162163,"threshold_uncertainty_score":0.06146175,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01085547320606907,"score_gpt":0.3114755059760926,"score_spread":0.3006200327700236,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}