{"id":"W4406669137","doi":"10.1073/pnas.2416886122","title":"Nav1.8, an analgesic target for nonpsychotomimetic phytocannabinoids","year":2025,"lang":"en","type":"article","venue":"Proceedings of the National Academy of Sciences","topic":"Cannabis and Cannabinoid Research","field":"Medicine","cited_by":18,"is_retracted":false,"has_abstract":true,"ca_institutions":"","funders":"Canadian Institutes of Health Research - Antimicrobial Resistance Research Initiative; National Center for Advancing Translational Sciences; National Institute of Neurological Disorders and Stroke; National Institute of General Medical Sciences; Yale University; National Institutes of Health; Rehabilitation Research and Development Service; Paralyzed Veterans of America; Canadian Institutes of Health Research; U.S. Department of Veterans Affairs","keywords":"Cannabidiol; Analgesic; Medicine; Nociceptor; Pharmacology; Sodium channel; Neuroscience; Adverse effect; Anesthesia; Nociception; Chemistry; Cannabis; Biology; Internal medicine; Receptor; Sodium","routes":{"ca_aff":false,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":true},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.00008573388,0.000221125,0.0002372581,0.0001849025,0.000271852,0.0002713926,0.0001929137,0.0002805577,0.003200072],"category_scores_gemma":[0.00008700138,0.00006819878,0.0002031047,0.0001186629,0.000282326,0.0002042041,0.0002010044,0.0005325744,0.0004285676],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0004331626,"about_ca_system_score_gemma":0.0004323711,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.001523257,"about_ca_topic_score_gemma":0.003587599,"domain_scores_codex":[0.999962,0.000005393697,0.000002410962,0.000008457724,0.00001095514,0.00001086185],"domain_scores_gemma":[0.9999738,0.000005136592,0.00000579506,0.000002566855,0.000006395562,0.000006185664],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.000436735,0.00005291708,0.0003732046,0.0005136675,0.00001318172,0.0002455592,0.00003484358,0.0001042951,0.9668599,0.001228069,0.0003880691,0.02974959],"study_design_scores_gemma":[0.0001325589,0.001684407,0.01571749,0.0002641972,0.0001229256,0.002645422,0.0002244168,0.001342155,0.9181337,0.002039533,0.05765122,0.00004206721],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.8347312,0.1180138,0.01594627,0.003230396,0.0006172794,0.0002701281,0.0007925979,0.0002381509,0.02616018],"genre_scores_gemma":[0.9451155,0.04064379,0.005975463,0.0006723127,0.00006754306,0.00007272752,0.0003173368,0.00001682903,0.007118589],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.003200072,"threshold_uncertainty_score":0.01070535,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.03915876751395045,"score_gpt":0.3792864000222325,"score_spread":0.340127632508282,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}