{"id":"W4406676917","doi":"10.3390/ijms26020793","title":"HERC1 E3 Ubiquitin Ligase Is Necessary for Autophagy Processes and for the Maintenance and Homeostasis of Vesicles in Motor Nerve Terminals, but Not for Proteasomal Activity","year":2025,"lang":"en","type":"article","venue":"International Journal of Molecular Sciences","topic":"Autophagy in Disease and Therapy","field":"Medicine","cited_by":2,"is_retracted":false,"has_abstract":true,"ca_institutions":"Lunenfeld-Tanenbaum Research Institute; Mount Sinai Hospital","funders":"Agencia Estatal de Investigación; Ministerio de Ciencia e Innovación; Ministerio de Economía y Competitividad; Junta de Andalucía; European Commission","keywords":"Ubiquitin ligase; Autophagy; Cell biology; Ubiquitin; Biology; Neuromuscular junction; Homeostasis; Neurotransmitter; Synaptic vesicle; Proteasome; Endocrinology; Biochemistry; Neuroscience; Central nervous system; Vesicle; Gene","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.00009109267,0.0004445211,0.0003953108,0.0003092489,0.0003491098,0.0002895383,0.000183925,0.0003502734,0.001303859],"category_scores_gemma":[0.0001048887,0.000130223,0.0003953513,0.0002572592,0.0002592022,0.0002152566,0.0003093932,0.0003144883,0.0006387871],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.000628787,"about_ca_system_score_gemma":0.0002790489,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.001113226,"about_ca_topic_score_gemma":0.00138989,"domain_scores_codex":[0.9998415,0.00001288106,0.00001761374,0.00004989002,0.00003938696,0.00003876252],"domain_scores_gemma":[0.9998797,0.000007325883,0.00005263656,0.00001118019,0.00001873636,0.00003037377],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0001753051,0.00001701727,0.001330548,0.0001191173,0.00002338596,0.0003501704,0.00001097997,0.00007803332,0.995383,0.000152934,0.0001256662,0.002233888],"study_design_scores_gemma":[0.00002485128,0.0001188953,0.03485413,0.00002147821,0.00005239316,0.003163633,0.00004775076,0.001188944,0.9528561,0.0001531017,0.007506799,0.00001193627],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.986936,0.006630627,0.003581925,0.0001802186,0.0000439075,0.00001713558,0.001054431,0.0001520944,0.00140373],"genre_scores_gemma":[0.9933726,0.001068682,0.001305049,0.00004672238,0.000007849844,0.00001752708,0.001455979,0.00002227864,0.002703354],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001303859,"threshold_uncertainty_score":0.004562199,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.02342404814154454,"score_gpt":0.34332551858862,"score_spread":0.3199014704470755,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}