{"id":"W4406682566","doi":"10.1016/j.jad.2025.01.101","title":"Simple dysmood disorder, a mild subtype of major depression, is not an inflammatory condition: Depletion of the compensatory immunoregulatory system","year":2025,"lang":"en","type":"article","venue":"Journal of Affective Disorders","topic":"Tryptophan and brain disorders","field":"Neuroscience","cited_by":10,"is_retracted":false,"has_abstract":false,"ca_institutions":"","funders":"Faculty of Medicine, Chulalongkorn University; Chulalongkorn University; Faculty of Medicine, University of British Columbia","keywords":"Depression (economics); Inflammation; Simple (philosophy); Medicine; Psychiatry; Psychology; Immunology; Internal medicine","routes":{"ca_aff":false,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":true},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0000914612,0.0002104205,0.0004470626,0.0002864409,0.0002132455,0.0002688917,0.0001372383,0.000251418,0.001248106],"category_scores_gemma":[0.0003462437,0.0001095838,0.0001066488,0.0001168609,0.0004392545,0.0001884676,0.0001978691,0.0002973384,0.000148913],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0002609653,"about_ca_system_score_gemma":0.0001958924,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0006086099,"about_ca_topic_score_gemma":0.001966886,"domain_scores_codex":[0.9999279,0.00001047553,0.00001164457,0.00001530882,0.00001871941,0.00001591769],"domain_scores_gemma":[0.9998239,0.0000203961,0.00006873116,0.00001579575,0.00001387599,0.00005735572],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"observational","study_design_scores_codex":[0.006418787,0.0004128811,0.2632844,0.0003792184,0.0002862985,0.02372916,0.000249424,0.0001025549,0.6504251,0.001511769,0.001200389,0.052],"study_design_scores_gemma":[0.0001460531,0.00114022,0.9556947,0.00003132336,0.00008159262,0.02591582,0.0001614687,0.0003529276,0.01431054,0.0005207788,0.001632388,0.00001230034],"study_design_candidate":"observational","study_design_consensus":null,"genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9971239,0.0006986828,0.000277329,0.0001335572,0.00002976661,0.00002361299,0.00007153617,0.00001417525,0.00162755],"genre_scores_gemma":[0.9990496,0.0001925869,0.0001738444,0.00008039371,0.00002272744,0.000006667335,0.00005854079,0.000002920587,0.0004126449],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001248106,"threshold_uncertainty_score":0.004175365,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.007718953172748168,"score_gpt":0.2527826209232686,"score_spread":0.2450636677505204,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}