{"id":"W4406693206","doi":"10.1001/jamapsychiatry.2024.4305","title":"Depressive Symptoms and Amyloid Pathology","year":2025,"lang":"en","type":"article","venue":"JAMA Psychiatry","topic":"Dementia and Cognitive Impairment Research","field":"Medicine","cited_by":20,"is_retracted":false,"has_abstract":true,"ca_institutions":"McGill University; Douglas Mental Health University Institute; Montreal Neurological Institute and Hospital","funders":"National Bioscience Database Center; National Institute of Neurological Disorders and Stroke; National Institute on Aging; Medizinische Fakultät der Albert-Ludwigs-Universität Freiburg; National Institute of Mental Health; Institut de Recherches Servier; Sahlgrenska Akademin; Instituto de Salud Carlos III; College of Medicine, Seoul National University; Tau Consortium; Genentech; National Institutes of Health; GIESKES-STRIJBIS FONDS; European Brain Council; Olav Thon Stiftelsen; Institut d’Investigacions Biomèdiques August Pi i Sunyer, Universitat de Barcelona; UK Dementia Research Institute; Centro de Investigación Biomédica en Red sobre Enfermedades Neurodegenerativas; European Federation of Pharmaceutical Industries and Associations; Institut National de la Santé et de la Recherche Médicale; H. Lundbeck A/S; Uniwersytet Jagielloński Collegium Medicum; University College London; Oryzon Genomics; Fondation pour la Recherche sur Alzheimer; Radboud Universitair Medisch Centrum; Eli Lilly and Company; Universidade de Lisboa; Eusko Jaurlaritza; Göteborgs Universitet; Universidade de Coimbra; Weill Cornell Medical College; University of Pennsylvania; Fujirebio Europe; University of Tokyo; Università degli Studi di Genova; International Atomic Energy Agency; School of Medicine and Public Health, University of Wisconsin-Madison; Novo Nordisk; Vetenskapsrådet; Banco Bilbao Vizcaya Argentaria; Kyowa Hakko Kirin; Sahlgrenska Universitetssjukhuset; Hjärnfonden; Sanofi; Leids Universitair Medisch Centrum; Eisai; McGill University; Univerzita Karlova v Praze; Generalitat de Catalunya; Wydział Lekarski, Uniwersytet Jagielloński Collegium Medicum; Julius Clinical; Stichting Dioraphte; European Regional Development Fund; Alzheimer's Research Trust; Seoul National University; Servier; Grifols; University of Texas at Dallas; ZonMw; Bayer Vital; Alzheimer Nederland; Japan Science and Technology Agency; Eberhard Karls Universität Tübingen; Schweizerischer Nationalfonds zur Förderung der Wissenschaftlichen Forschung; Technische Universität München; Nederlandse Organisatie voor Wetenschappelijk Onderzoek; Deutsche Forschungsgemeinschaft; National Science Foundation; Université de Lausanne; HORIZON EUROPE Framework Programme; Albert-Ludwigs-Universität Freiburg; Indian Council of Medical Research; Vlaamse regering; National Research Foundation; Foundation for Barnes-Jewish Hospital; National Institute for Health and Care Research; Universitätsmedizin Göttingen; Union Chimique Belge; Good Ventures Foundation; Centene Corporation; Roche Nederland; National and Kapodistrian University of Athens; Health~Holland; Alzheimer's Association; Hersenstichting; Brigham and Women's Hospital; Avid Radiopharmaceuticals; Target ALS; Pfizer; EU Joint Programme – Neurodegenerative Disease Research; Siemens Healthineers; Fundació la Marató de TV3; Commissariat à l'Énergie Atomique et aux Énergies Alternatives; Demensförbundet; Cure Alzheimer's Fund; Karolinska Institutet; Turun Yliopisto; Yale University; Alzheimer's Drug Discovery Foundation; University of Wisconsin-Madison; European Commission; Prothena; Faculty of Medicine, McGill University; Celgene; BrightFocus Foundation; Harvard University; F. Hoffmann-La Roche; Biogen; Ionis Pharmaceuticals; Carl von Ossietzky Universität Oldenburg; Università di Bologna; AstraZeneca; Bristol-Myers Squibb; Association for Frontotemporal Degeneration; Danone; Familjen Erling-Perssons Stiftelse; Cilag; Amgen; Stiftelsen för Gamla Tjänarinnor; Lunds Universitet; Fundación BBVA","keywords":"Biomarker; Medicine; Dementia; Depression (economics); Geriatric Depression Scale; Internal medicine; Clinical Dementia Rating; Population; Apolipoprotein E; Amyloid (mycology); Psychiatry; Pathology; Oncology; Cognition; Depressive symptoms; Disease","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001233287,0.00009507057,0.0001575833,0.0001529696,0.00007679533,0.00003287774,0.00005910138,0.0000973006,0.0002236264],"category_scores_gemma":[0.00005666285,0.00007896154,0.0000497392,0.000170764,0.00009878373,0.00005501033,0.00007849654,0.0002195579,0.00004141741],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00001427789,"about_ca_system_score_gemma":0.0001386913,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.000006484591,"about_ca_topic_score_gemma":0.000005658351,"domain_scores_codex":[0.9991907,0.00004742251,0.0001365089,0.0002538537,0.0001390146,0.0002324559],"domain_scores_gemma":[0.9995804,0.00003740336,0.00002656221,0.0001846657,0.00007855801,0.00009239212],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"observational","study_design_gemma":"observational","study_design_scores_codex":[0.000208597,0.0001752361,0.9331287,0.0001109448,0.0001067715,0.00004312984,0.00003392333,4.490506e-8,0.0009525944,0.003911461,0.01400796,0.04732069],"study_design_scores_gemma":[0.003694966,0.0002840627,0.981185,0.0001418355,0.0001105684,0.00008708461,0.0001497928,0.00002951549,0.0006421595,0.003461694,0.01014,0.00007335233],"study_design_candidate":"observational","study_design_consensus":"observational","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9091645,0.002095264,0.0003256366,0.01202109,0.0004127008,0.0002841338,0.000004618883,0.00004414526,0.07564792],"genre_scores_gemma":[0.9861575,0.0001445273,0.0004519789,0.006248284,0.0001592705,0.00004651641,0.0000123773,0.000008695824,0.006770859],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.076993,"threshold_uncertainty_score":0.3219958,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.005339399787295199,"score_gpt":0.2975845718156558,"score_spread":0.2922451720283606,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). 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