{"id":"W4406693435","doi":"10.1016/j.jaad.2024.11.079","title":"Dupilumab treatment restores lesional and nonlesional skin barrier function in adults and adolescents with atopic dermatitis irrespective of the filaggrin genotype: Results from an open-label, healthy-control–matched, phase 4 clinical study (BALISTAD)","year":2025,"lang":"en","type":"article","venue":"Journal of the American Academy of Dermatology","topic":"Dermatology and Skin Diseases","field":"Medicine","cited_by":10,"is_retracted":false,"has_abstract":false,"ca_institutions":"Innovaderm (Canada)","funders":"Regeneron Pharmaceuticals; Sanofi","keywords":"Medicine; Atopic dermatitis; Filaggrin; Dermatology; Open label; Dupilumab; Skin barrier; Genotype; Randomized controlled trial; Surgery","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0007030221,0.0005770277,0.001228376,0.0002559806,0.0002869791,0.0005176012,0.0004008588,0.0004907626,0.001235663],"category_scores_gemma":[0.0004506944,0.0002261002,0.0005648354,0.0001697451,0.000385189,0.0004150168,0.0001751061,0.001001371,0.0002286989],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0003571831,"about_ca_system_score_gemma":0.0003804214,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.000790856,"about_ca_topic_score_gemma":0.002263907,"domain_scores_codex":[0.9997494,0.00009143852,0.00001804295,0.000049042,0.0000346604,0.00005744658],"domain_scores_gemma":[0.9997563,0.00005308374,0.00005299855,0.00001845374,0.00002144832,0.00009765073],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"randomized_trial","study_design_gemma":"nonrandomized_trial","study_design_scores_codex":[0.5570079,0.05645371,0.03603629,0.001621455,0.003353789,0.0007285583,0.0006069734,0.0008202619,0.09256423,0.0001714568,0.002932237,0.2477031],"study_design_scores_gemma":[0.2266336,0.491028,0.2633444,0.0001201588,0.002188322,0.001536133,0.00041035,0.001643693,0.00915808,0.000154906,0.003721065,0.00006130167],"study_design_candidate":"nonrandomized_trial","study_design_consensus":null,"genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9984086,0.001014365,0.00005715356,0.0000430762,0.00002722057,0.00008705516,0.0001007247,0.00001572344,0.000246116],"genre_scores_gemma":[0.9981988,0.0007354856,0.0002511247,0.0001544552,0.00003982111,0.00008659111,0.0002224636,0.000005377085,0.0003058064],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001235663,"threshold_uncertainty_score":0.004133701,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.02483762802459707,"score_gpt":0.3786223494193535,"score_spread":0.3537847213947564,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}