{"id":"W4406699474","doi":"10.1093/ecco-jcc/jjae190.1146","title":"P0972 Higher vedolizumab clearance associates with poor therapeutic outcomes during maintenance therapy of vedolizumab in Crohn’s disease","year":2025,"lang":"en","type":"article","venue":"Journal of Crohn s and Colitis","topic":"Inflammatory Bowel Disease","field":"Biochemistry, Genetics and Molecular Biology","cited_by":0,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of Alberta","funders":"","keywords":"Vedolizumab; Medicine; Crohn's disease; Maintenance therapy; Disease; Internal medicine; Intensive care medicine; Chemotherapy","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0009464117,0.0002402261,0.0005792881,0.0005674633,0.0002507226,0.0006853095,0.0002186743,0.0003874815,0.001130636],"category_scores_gemma":[0.003064052,0.0001503344,0.0003701918,0.0006056963,0.000286145,0.0004428601,0.0003071609,0.0004886884,0.0002139328],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0002159169,"about_ca_system_score_gemma":0.000140914,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0004242882,"about_ca_topic_score_gemma":0.0003006806,"domain_scores_codex":[0.9993058,0.0002259889,0.0001094618,0.0001462916,0.0001234253,0.00008892205],"domain_scores_gemma":[0.9969842,0.000944323,0.001416046,0.0001248911,0.000192353,0.0003382639],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"observational","study_design_gemma":"observational","study_design_scores_codex":[0.001751272,0.00004906431,0.9920088,0.00001825541,0.00006965801,0.0002024767,0.00003236805,0.0001037495,0.001290717,0.00001875137,0.00007589003,0.004378853],"study_design_scores_gemma":[0.00002998014,0.0004532446,0.9974437,0.000006232583,0.00005527983,0.0009605919,0.00003940534,0.0005536475,0.0002664279,0.00002740159,0.0001595761,0.000004518639],"study_design_candidate":"observational","study_design_consensus":"observational","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9993281,0.0003710957,0.00005614389,0.0000214402,0.000002559778,0.000002114754,0.00005089583,0.000002314521,0.0001653224],"genre_scores_gemma":[0.9997894,0.00003697566,0.00002981648,0.000008215024,0.000007474601,0.00000196541,0.00008887494,0.000001396894,0.00003581723],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001130636,"threshold_uncertainty_score":0.005005181,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.006116894390218679,"score_gpt":0.2406942377482728,"score_spread":0.2345773433580542,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}