{"id":"W4406699644","doi":"10.1093/ecco-jcc/jjae190.0989","title":"P0815 Oral alpha 4 beta 7 (α4β7) integrin antagonist EA1080 (NSHO-101) demonstrates target engagement and α4β7 integrin receptor occupancy following once-daily administration in healthy volunteers","year":2025,"lang":"en","type":"article","venue":"Journal of Crohn s and Colitis","topic":"Cell Adhesion Molecules Research","field":"Medicine","cited_by":1,"is_retracted":false,"has_abstract":true,"ca_institutions":"Western University","funders":"","keywords":"Medicine; Integrin; Alpha (finance); Pharmacology; Antagonist; BETA (programming language); Receptor; Internal medicine; Surgery","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.000312665,0.0003021162,0.0004078786,0.0001088299,0.0001508204,0.0003116101,0.0001868365,0.0003597738,0.001704728],"category_scores_gemma":[0.0002728062,0.0001775466,0.0001781002,0.0001002513,0.000221007,0.0002194372,0.0001152164,0.0006179541,0.0004580172],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0001606919,"about_ca_system_score_gemma":0.0003003935,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0007288307,"about_ca_topic_score_gemma":0.001136022,"domain_scores_codex":[0.9998187,0.00005738332,0.00001033501,0.00004756474,0.00003708304,0.00002891417],"domain_scores_gemma":[0.9999051,0.0000178661,0.00002455282,0.00001123931,0.00001219722,0.00002903358],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"nonrandomized_trial","study_design_scores_codex":[0.02041125,0.004230747,0.002890002,0.000140652,0.00006325579,0.0002207654,0.0001089557,0.000410761,0.9353087,0.0000480617,0.001092027,0.03507482],"study_design_scores_gemma":[0.00596092,0.5101148,0.0804564,0.00003622807,0.0002653838,0.002243415,0.0002544056,0.005049713,0.3883039,0.0001404163,0.007123688,0.00005075211],"study_design_candidate":"nonrandomized_trial","study_design_consensus":null,"genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9980224,0.0004478261,0.0005958218,0.00003561145,0.00001666072,0.00009218365,0.000230545,0.00005640697,0.0005025927],"genre_scores_gemma":[0.9964837,0.0003048204,0.0007890746,0.00009156166,0.00001419555,0.0001174534,0.0004509753,0.00001352574,0.001734658],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001704728,"threshold_uncertainty_score":0.005702853,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.02539403658958697,"score_gpt":0.3389210488547146,"score_spread":0.3135270122651276,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}