{"id":"W4406704158","doi":"10.1093/ecco-jcc/jjae190.0371","title":"P0197 Comparison of pharmacodynamic and mechanistic response of guselkumab intravenous and subcutaneous induction in moderately to severely active Crohn’s disease: molecular analysis of the GRAVITI and GALAXI Phase 3 studies","year":2025,"lang":"en","type":"article","venue":"Journal of Crohn s and Colitis","topic":"Inflammatory Bowel Disease","field":"Biochemistry, Genetics and Molecular Biology","cited_by":0,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of Calgary; Western University","funders":"","keywords":"Medicine; Crohn's disease; Pharmacodynamics; Disease; Pharmacology; Pharmacokinetics; Internal medicine","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.00144782,0.0003587077,0.001211965,0.0002831754,0.0001333423,0.0007968135,0.0003551079,0.0004544781,0.00210452],"category_scores_gemma":[0.0008782672,0.0001966317,0.0007401684,0.000372823,0.0005950927,0.0003617342,0.0002269687,0.001290843,0.0003421212],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0003920979,"about_ca_system_score_gemma":0.0004036308,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0002305278,"about_ca_topic_score_gemma":0.0005104586,"domain_scores_codex":[0.9995152,0.0002546853,0.00003270254,0.00005762235,0.00007439397,0.00006555592],"domain_scores_gemma":[0.9993793,0.0002005123,0.0001593682,0.00004537365,0.00004710694,0.0001683824],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"randomized_trial","study_design_gemma":"observational","study_design_scores_codex":[0.6764157,0.008361991,0.01667497,0.00064238,0.001432237,0.0002090925,0.0002064459,0.001685686,0.197368,0.0003148494,0.001491836,0.09519679],"study_design_scores_gemma":[0.1536491,0.6883355,0.1087078,0.00006479851,0.001642759,0.0005733443,0.0001776098,0.002859422,0.03806955,0.0003852173,0.005474752,0.00006011525],"study_design_candidate":"observational","study_design_consensus":null,"genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9966744,0.001649924,0.0002929425,0.0001524861,0.00002389414,0.0001531751,0.0003388241,0.00002543492,0.0006890293],"genre_scores_gemma":[0.9970636,0.0005770387,0.0005319693,0.0001629478,0.00005891477,0.0002053296,0.0007144607,0.00001261389,0.0006730951],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.00210452,"threshold_uncertainty_score":0.007656932,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01128846751852192,"score_gpt":0.3184816791856588,"score_spread":0.3071932116671369,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}