{"id":"W4406704516","doi":"10.1093/ecco-jcc/jjae190.0735","title":"P0561 Sustained Corticosteroid-Sparing Effects of Upadacitinib Maintenance Therapy in Patients With Moderate-to-Severe Crohn’s Disease: 2-Year Results From the U-ENDURE Long-Term Extension Study","year":2025,"lang":"en","type":"article","venue":"Journal of Crohn s and Colitis","topic":"Inflammatory Bowel Disease","field":"Biochemistry, Genetics and Molecular Biology","cited_by":1,"is_retracted":false,"has_abstract":true,"ca_institutions":"Western University","funders":"","keywords":"Medicine; Corticosteroid; Crohn's disease; Maintenance therapy; Inflammatory bowel disease; Term (time); Disease; Internal medicine; Surgery; Chemotherapy","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.002273816,0.0005660693,0.00141812,0.0002634749,0.0003001962,0.0009413873,0.0004648875,0.0007171548,0.001129368],"category_scores_gemma":[0.001225202,0.0002075003,0.001522625,0.0002831965,0.0003811487,0.0007939984,0.0004480569,0.001343728,0.0003221802],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0003463495,"about_ca_system_score_gemma":0.0005053959,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0004824437,"about_ca_topic_score_gemma":0.001212531,"domain_scores_codex":[0.9993811,0.0002479956,0.00007413026,0.00009064595,0.00009099372,0.0001151242],"domain_scores_gemma":[0.9985146,0.0002491134,0.000464594,0.0001219688,0.0001465049,0.0005032569],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"randomized_trial","study_design_gemma":"observational","study_design_scores_codex":[0.6119636,0.02957643,0.1493816,0.001654325,0.006021183,0.0005875205,0.000416955,0.001357091,0.02651358,0.0001547949,0.003275039,0.1690979],"study_design_scores_gemma":[0.1284183,0.4392629,0.4150425,0.0001959206,0.005270772,0.0008146914,0.0002125758,0.00190495,0.004583397,0.0001612856,0.0040404,0.0000924826],"study_design_candidate":"observational","study_design_consensus":null,"genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9944396,0.004197226,0.0001218643,0.0001005497,0.0000283215,0.0001664739,0.0004205434,0.00001707527,0.0005084971],"genre_scores_gemma":[0.997407,0.0008101266,0.0002061158,0.0002291277,0.00008836635,0.0001084665,0.0007948734,0.000002906174,0.0003530559],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.002273816,"threshold_uncertainty_score":0.01202524,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.004971378134405887,"score_gpt":0.2290919945957928,"score_spread":0.224120616461387,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}