{"id":"W4406705105","doi":"10.1093/ecco-jcc/jjae190.0098","title":"DOP059 Lack of significance of treatment-emergent anti-drug antibodies on efficacy of mirikizumab in patients with moderately-to-severely active Crohn’s Disease: Results from the VIVID-1 study","year":2025,"lang":"en","type":"article","venue":"Journal of Crohn s and Colitis","topic":"Immunodeficiency and Autoimmune Disorders","field":"Immunology and Microbiology","cited_by":0,"is_retracted":false,"has_abstract":true,"ca_institutions":"Western University","funders":"","keywords":"Medicine; Crohn's disease; Drug; Disease; Antibody; Efficacy; Internal medicine; Gastroenterology; Immunology; Pharmacology","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.002646128,0.0003715011,0.001705338,0.0001523539,0.0001674411,0.0007149142,0.0004931342,0.000577078,0.002275428],"category_scores_gemma":[0.002051323,0.0002079081,0.001256309,0.0002135733,0.0004313958,0.0004542862,0.0003149615,0.001040814,0.000313464],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0003627719,"about_ca_system_score_gemma":0.0004035931,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0002335312,"about_ca_topic_score_gemma":0.0005006815,"domain_scores_codex":[0.9983707,0.001059945,0.000140539,0.0001690861,0.0001593976,0.0001003269],"domain_scores_gemma":[0.9981025,0.0007849084,0.0004156492,0.000148851,0.00009094345,0.0004572566],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"randomized_trial","study_design_gemma":"randomized_trial","study_design_scores_codex":[0.8578099,0.004275509,0.04431671,0.001219723,0.00344771,0.0001876991,0.0001710706,0.0004577711,0.02207477,0.0001719404,0.001156799,0.06471047],"study_design_scores_gemma":[0.2162985,0.4325519,0.3314847,0.000202904,0.005097498,0.000847648,0.0001933679,0.001276606,0.005690956,0.0003471959,0.005923428,0.00008529362],"study_design_candidate":"randomized_trial","study_design_consensus":"randomized_trial","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9914881,0.006202355,0.0001645321,0.0002022346,0.00006113625,0.0001647181,0.0006819067,0.00001147086,0.001023718],"genre_scores_gemma":[0.9975095,0.0008160474,0.0002479676,0.0002082155,0.0000839987,0.00008634485,0.0007732348,0.000003514821,0.000271296],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.002646128,"threshold_uncertainty_score":0.01399428,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01491112518777125,"score_gpt":0.270027470877553,"score_spread":0.2551163456897817,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}