{"id":"W4406705244","doi":"10.1093/ecco-jcc/jjae190.0041","title":"DOP002 Efficacy and safety of upadacitinib after 4 years of treatment in patients with moderately to severely active ulcerative colitis: interim long-term data from the phase 3 open-label extension study (U-ACTIVATE)","year":2025,"lang":"en","type":"article","venue":"Journal of Crohn s and Colitis","topic":"Inflammatory Bowel Disease","field":"Biochemistry, Genetics and Molecular Biology","cited_by":3,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of Calgary","funders":"","keywords":"Medicine; Ulcerative colitis; Open label; Interim; Interim analysis; Internal medicine; Clinical trial; Gastroenterology; Surgery","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.002546637,0.0006526965,0.001595086,0.0003040223,0.0004106297,0.001118157,0.0005391042,0.001010115,0.004253652],"category_scores_gemma":[0.001768629,0.0002558137,0.001573008,0.0003175642,0.0004740063,0.0007960318,0.0004020741,0.001989459,0.0007569877],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.000472692,"about_ca_system_score_gemma":0.0006719665,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0006220645,"about_ca_topic_score_gemma":0.001549748,"domain_scores_codex":[0.9991181,0.0004908446,0.00007520378,0.00007732426,0.00009828741,0.0001402461],"domain_scores_gemma":[0.9981419,0.0005196236,0.0005214658,0.0001511205,0.000191653,0.0004741159],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"randomized_trial","study_design_gemma":"nonrandomized_trial","study_design_scores_codex":[0.8655569,0.01203191,0.01576425,0.0009404292,0.002015802,0.000250502,0.00016524,0.000906745,0.01442606,0.0001178405,0.005174283,0.08265006],"study_design_scores_gemma":[0.3281801,0.5379997,0.1102344,0.0002136867,0.003384066,0.0005875822,0.0001751197,0.00162062,0.008604908,0.0002954272,0.008591129,0.0001132714],"study_design_candidate":"nonrandomized_trial","study_design_consensus":null,"genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.980587,0.008300534,0.0005522294,0.0004079708,0.0001480796,0.001301123,0.004887547,0.0000820908,0.003733383],"genre_scores_gemma":[0.9889416,0.001390588,0.0006716693,0.000629587,0.0002197057,0.0006857858,0.004969126,0.0000174195,0.002474379],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.004253652,"threshold_uncertainty_score":0.01422989,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.02603368315695873,"score_gpt":0.3221435530738448,"score_spread":0.296109869916886,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}