{"id":"W4406705372","doi":"10.1093/ecco-jcc/jjae190.0039a","title":"OP40 Duvakitug (TEV-48574), an anti-TL1a monoclonal antibody, demonstrates efficacy and favourable safety as an induction treatment in adults with moderately to severely active Crohn’s disease: results from a phase 2b, randomised, double-blind, placebo-controlled dose-ranging, basket trial (RELIEVE UCCD)","year":2025,"lang":"en","type":"article","venue":"Journal of Crohn s and Colitis","topic":"Inflammatory Bowel Disease","field":"Biochemistry, Genetics and Molecular Biology","cited_by":7,"is_retracted":false,"has_abstract":true,"ca_institutions":"Western University","funders":"","keywords":"Medicine; Crohn's disease; Monoclonal antibody; Monoclonal; Disease; Immunology; Internal medicine; Antibody","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.002012222,0.001281318,0.002352508,0.0003996826,0.0003388357,0.0008212845,0.0007129357,0.00139801,0.006051166],"category_scores_gemma":[0.001122727,0.0005191186,0.001188558,0.0004694504,0.0008626234,0.0007420495,0.0004116438,0.002195045,0.0007596927],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00053993,"about_ca_system_score_gemma":0.0006030638,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0005705813,"about_ca_topic_score_gemma":0.00164002,"domain_scores_codex":[0.9993712,0.0003538111,0.00005402319,0.00008509455,0.00005851247,0.00007736738],"domain_scores_gemma":[0.9991448,0.0002050827,0.0002539171,0.00003891138,0.00005622091,0.000301084],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"randomized_trial","study_design_gemma":"randomized_trial","study_design_scores_codex":[0.9373513,0.007758281,0.002817476,0.001631556,0.0008979826,0.0000927097,0.00006443149,0.0002962662,0.01367158,0.00009643925,0.001904802,0.03341717],"study_design_scores_gemma":[0.8428384,0.1438367,0.009300871,0.00006124128,0.0006229127,0.0001325196,0.00002395953,0.0002615813,0.001524988,0.00006685233,0.001308683,0.00002128388],"study_design_candidate":"randomized_trial","study_design_consensus":"randomized_trial","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9792694,0.01178838,0.0003965662,0.0008695327,0.0002067805,0.002672076,0.002613418,0.0001209757,0.00206284],"genre_scores_gemma":[0.9859151,0.004741053,0.001146421,0.0009936679,0.0003902298,0.001892033,0.002756855,0.00002742365,0.00213728],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.006051166,"threshold_uncertainty_score":0.02024311,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01210070286262169,"score_gpt":0.2962794745477864,"score_spread":0.2841787716851647,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}