{"id":"W4406705517","doi":"10.1093/ecco-jcc/jjae190.0009","title":"OP09 Dose intensification of vedolizumab is not effective in inducing endoscopic response in Crohn’s disease patients with endoscopic primary non-response","year":2025,"lang":"en","type":"article","venue":"Journal of Crohn s and Colitis","topic":"Inflammatory Bowel Disease","field":"Biochemistry, Genetics and Molecular Biology","cited_by":1,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of Alberta","funders":"","keywords":"Medicine; Vedolizumab; Crohn's disease; Endoscopy; Inflammatory bowel disease; Complete response; Ulcerative colitis; Internal medicine; Disease; Gastroenterology; Chemotherapy","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.001296357,0.000229559,0.001788743,0.0001287332,0.0001335108,0.0004544842,0.0003481318,0.0004762559,0.003726021],"category_scores_gemma":[0.001342724,0.0001735527,0.0009198315,0.0001441397,0.0003155043,0.0004213525,0.0002308177,0.001234731,0.0004479422],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0002299836,"about_ca_system_score_gemma":0.0002351739,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0001121707,"about_ca_topic_score_gemma":0.000231169,"domain_scores_codex":[0.9992735,0.0003971981,0.00007816638,0.00008631082,0.00005999612,0.0001048167],"domain_scores_gemma":[0.9988794,0.0004498248,0.0001895956,0.0001265792,0.00005297106,0.0003016345],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"randomized_trial","study_design_gemma":"nonrandomized_trial","study_design_scores_codex":[0.7403538,0.01488037,0.01699234,0.001441243,0.001042145,0.0004533166,0.0001624152,0.000625056,0.03570655,0.0001596124,0.001366275,0.186817],"study_design_scores_gemma":[0.1752616,0.6711704,0.1353601,0.0002360353,0.001127045,0.0009026412,0.0001090577,0.001505208,0.00966104,0.0002267897,0.004401459,0.00003857192],"study_design_candidate":"nonrandomized_trial","study_design_consensus":null,"genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9958961,0.002733208,0.0001382011,0.000110898,0.00005020743,0.0001701354,0.00008533343,0.00001780116,0.000798162],"genre_scores_gemma":[0.9985961,0.0004368348,0.0002268886,0.0001140553,0.00006461836,0.00008700428,0.0001761797,0.000003763687,0.0002945524],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.003726021,"threshold_uncertainty_score":0.01246482,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.004574470863677003,"score_gpt":0.2398138163352634,"score_spread":0.2352393454715864,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}