{"id":"W4406705791","doi":"10.1093/ecco-jcc/jjae190.0053","title":"DOP014 Efficacy and safety up to 3 years of risankizumab maintenance treatment in patients with moderately to severely active ulcerative colitis: interim results from phase 3 COMMAND open-label extension study","year":2025,"lang":"en","type":"article","venue":"Journal of Crohn s and Colitis","topic":"Inflammatory Bowel Disease","field":"Biochemistry, Genetics and Molecular Biology","cited_by":1,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of Calgary","funders":"","keywords":"Medicine; Ulcerative colitis; Interim; Open label; Internal medicine; Maintenance therapy; Phases of clinical research; Interim analysis; Adverse effect; Surgery; Physical therapy; Clinical trial; Chemotherapy","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.002738999,0.0009955016,0.001883374,0.0004067059,0.0003600768,0.001067078,0.0006279264,0.0008977648,0.003964085],"category_scores_gemma":[0.00144764,0.0003084145,0.001796277,0.0004632108,0.0004831011,0.000730028,0.0004158984,0.001777608,0.001000941],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0006018812,"about_ca_system_score_gemma":0.001245713,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0005617882,"about_ca_topic_score_gemma":0.001440013,"domain_scores_codex":[0.9992143,0.0003974682,0.00006396751,0.00007792001,0.0001131686,0.0001332285],"domain_scores_gemma":[0.9987853,0.0002274147,0.0003764845,0.0001065044,0.0001366887,0.0003675873],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"randomized_trial","study_design_gemma":"randomized_trial","study_design_scores_codex":[0.8334544,0.01781585,0.01414824,0.0008996113,0.001908599,0.00021953,0.0002034538,0.001939231,0.02332545,0.0001816716,0.006253244,0.09965075],"study_design_scores_gemma":[0.3473788,0.5772145,0.05742122,0.0001051572,0.001872806,0.0003327559,0.00009274438,0.001549452,0.006064627,0.0003016319,0.007604774,0.00006149457],"study_design_candidate":"randomized_trial","study_design_consensus":"randomized_trial","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9841045,0.005052123,0.0005791492,0.0004748819,0.0001270689,0.001365151,0.004897169,0.0002049712,0.003194933],"genre_scores_gemma":[0.9849978,0.00146014,0.001379813,0.0006363399,0.0002550911,0.001430633,0.007557102,0.00003809997,0.002244921],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.003964085,"threshold_uncertainty_score":0.01448536,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01528489819192888,"score_gpt":0.3016028961101547,"score_spread":0.2863179979182259,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}