{"id":"W4406715008","doi":"10.1002/pds.70104","title":"Hepatobiliary Adverse Events Associated With the <scp>KRAS p.G12C</scp> Inhibitor Sotorasib","year":2025,"lang":"en","type":"article","venue":"Pharmacoepidemiology and Drug Safety","topic":"Colorectal Cancer Treatments and Studies","field":"Medicine","cited_by":3,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of British Columbia","funders":"","keywords":"Medicine; Adverse Event Reporting System; Pharmacovigilance; Adverse effect; KRAS; Internal medicine; Gastroenterology; Intensive care medicine; Pharmacology; Cancer; Colorectal cancer","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.006536605,0.0002548457,0.0005431369,0.0008852783,0.0002520545,0.0008397276,0.0002273572,0.0003215818,0.002710884],"category_scores_gemma":[0.01204683,0.0001236528,0.001194422,0.001529584,0.0003568461,0.0003745583,0.0003927928,0.0006090457,0.0002149131],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0006222412,"about_ca_system_score_gemma":0.0009047515,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.001051187,"about_ca_topic_score_gemma":0.001657955,"domain_scores_codex":[0.9928061,0.003335075,0.001116711,0.0005490893,0.002032025,0.0001609896],"domain_scores_gemma":[0.9749489,0.009163265,0.01331076,0.0008100736,0.001425252,0.0003417022],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"observational","study_design_gemma":"observational","study_design_scores_codex":[0.009731014,0.0002744649,0.7387637,0.007711397,0.006043156,0.001638696,0.0003321042,0.002154032,0.005385024,0.001017361,0.006185046,0.220764],"study_design_scores_gemma":[0.0005857211,0.003571672,0.923476,0.002232124,0.006654878,0.009834762,0.0002142748,0.003008441,0.01055782,0.001725799,0.03807013,0.00006841204],"study_design_candidate":"observational","study_design_consensus":"observational","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.8594779,0.1006987,0.007368865,0.003054611,0.0001822852,0.000843028,0.008614036,0.0001919614,0.01956861],"genre_scores_gemma":[0.9851792,0.009465177,0.001774809,0.0007011566,0.000124989,0.0001289153,0.001889145,0.00001909849,0.0007174202],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.006536605,"threshold_uncertainty_score":0.03456926,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01597102757338948,"score_gpt":0.3146697842013538,"score_spread":0.2986987566279644,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}